Several biologically active molecules including nutrients can affect the vascular endothelium which becomes dysfunctional and, as a consequence, predisposes to atherosclerosis. However, the impact of the intake of sodium and polyunsaturated fatty acids on carotid atherosclerosis in a population of elderly women has scarcely been studied. Our aim was to investigate the association between carotid intima-media thickness and atherosclerotic plaque and nutrient intake in asymptomatic elderly women. Carotid atherosclerosis was determined by duplex ultrasound in 108 elderly women. Dietary intake was assessed by a combination of a 24-hour recall and a 7-day food record. A physical examination and laboratory tests were performed. We found an association between the C-IMT and polyunsaturated fatty acid (negative, B = −0.014; p = 0.03; CI −0.027/−0.001) and sodium (positive, r = 0.16; P = 0.09) intake. When linoleic acid was added to the multivariable regression analysis instead of polyunsaturated fatty acids, C-IMT was associated with linoleic acid (B = −0.017; p = 0.02; CI −0.032/−0.003). In normotensive women we found a positive association between the C-IMT and sodium intake. The atherosclerotic plaque prevalence increased with the increase in sodium intake (66% vs 90% Tertile I vs Tertile III; p = 0.02). Iin conclusion, A low salt diet to a level of about 1.5 g/d and a polyunsaturated fatty acid intake of >9 g/d were found to be associate with a low atherosclerotic plaque prevalence in an elderly female population. Sodium and polyunsaturated fatty acids-mediated functional changes of the carotid endothelium may be implicated in atherosclerosis development.

Relationship between high sodium and low PUFA intake and carotid atherosclerosis in elderly women / E. Mazza, Y. Ferro, T. Lamprinoudi, C. Gazzaruso, P. Doldo, A. Pujia, T. Montalcini. - In: EXPERIMENTAL GERONTOLOGY. - ISSN 0531-5565. - 108(2018), pp. 256-261. [10.1016/j.exger.2018.05.004]

Relationship between high sodium and low PUFA intake and carotid atherosclerosis in elderly women

C. Gazzaruso;
2018

Abstract

Several biologically active molecules including nutrients can affect the vascular endothelium which becomes dysfunctional and, as a consequence, predisposes to atherosclerosis. However, the impact of the intake of sodium and polyunsaturated fatty acids on carotid atherosclerosis in a population of elderly women has scarcely been studied. Our aim was to investigate the association between carotid intima-media thickness and atherosclerotic plaque and nutrient intake in asymptomatic elderly women. Carotid atherosclerosis was determined by duplex ultrasound in 108 elderly women. Dietary intake was assessed by a combination of a 24-hour recall and a 7-day food record. A physical examination and laboratory tests were performed. We found an association between the C-IMT and polyunsaturated fatty acid (negative, B = −0.014; p = 0.03; CI −0.027/−0.001) and sodium (positive, r = 0.16; P = 0.09) intake. When linoleic acid was added to the multivariable regression analysis instead of polyunsaturated fatty acids, C-IMT was associated with linoleic acid (B = −0.017; p = 0.02; CI −0.032/−0.003). In normotensive women we found a positive association between the C-IMT and sodium intake. The atherosclerotic plaque prevalence increased with the increase in sodium intake (66% vs 90% Tertile I vs Tertile III; p = 0.02). Iin conclusion, A low salt diet to a level of about 1.5 g/d and a polyunsaturated fatty acid intake of >9 g/d were found to be associate with a low atherosclerotic plaque prevalence in an elderly female population. Sodium and polyunsaturated fatty acids-mediated functional changes of the carotid endothelium may be implicated in atherosclerosis development.
Atherosclerosis; Carotid; Elderly; PUFA; Sodium; Women
Settore MED/13 - Endocrinologia
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/859389
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