Nanotechnology and nanoparticles (NPs) are at the forefront of modern research, particularly in the case of healthcare therapeutic applications. Polymeric NPs, specifically, hold high promise for these purposes, including towards oral diseases. Careful optimisation of the production of polymeric NPs, however, is required to generate a product which can be easily translated from a laboratory environment to the actual clinical usage. Indeed, considerations such as biocompatibility, biodistribution, and biodegradability are paramount. Moreover, a pre-clinical assessment in adequate in vitro, ex vivo or in vivo model is also required. Last but not least, considerations for the scale-up are also important, together with an appropriate clinical testing pathway. This review aims to eviscerate the above topics, sourcing at examples from the recent literature to put in context the current most burdening oral diseases and the most promising polymeric NPs which would be suitable against them.

Engineering Polymeric Nanosystems against Oral Diseases / V. Mercadante, E. Scarpa, V. De Matteis, L. Rizzello, A. Poma. - In: MOLECULES. - ISSN 1420-3049. - 26:8(2021 Apr), pp. 2229.1-2229.35. [10.3390/molecules26082229]

Engineering Polymeric Nanosystems against Oral Diseases

E. Scarpa
Secondo
;
L. Rizzello
Penultimo
;
A. Poma
Ultimo
2021

Abstract

Nanotechnology and nanoparticles (NPs) are at the forefront of modern research, particularly in the case of healthcare therapeutic applications. Polymeric NPs, specifically, hold high promise for these purposes, including towards oral diseases. Careful optimisation of the production of polymeric NPs, however, is required to generate a product which can be easily translated from a laboratory environment to the actual clinical usage. Indeed, considerations such as biocompatibility, biodistribution, and biodegradability are paramount. Moreover, a pre-clinical assessment in adequate in vitro, ex vivo or in vivo model is also required. Last but not least, considerations for the scale-up are also important, together with an appropriate clinical testing pathway. This review aims to eviscerate the above topics, sourcing at examples from the recent literature to put in context the current most burdening oral diseases and the most promising polymeric NPs which would be suitable against them.
nanotechnologypolymeric nanoparticlesoral diseasesoral medicinecariesrestorative dentistryendodontologyperiodontologyoral cancerpre-clinical modelsclinical studies;
Settore BIO/10 - Biochimica
Settore BIO/09 - Fisiologia
Settore BIO/11 - Biologia Molecolare
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/858874
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