All these data shed light on the evolution of the centromeric sequences in Primates. Our results suggest radical differences in the structure, organization, and evolution of alpha-satellite DNA among different primate species, supporting the notion that 1) all the centromeric sequence in Primates evolved by genomic amplification, unequal crossover, and sequence homogenization using a 171 bp monomer as the basic seeding unit and 2) centromeric function is linked to relatively short repeated elements, more than higher-order structure. Moreover, our data indicate that complex higher-order repeat structures are a peculiarity of the hominid lineage, showing the more complex organization in humans.
New insights into centromere organization and evolution from the white-cheeked gibbon and marmoset / A. Cellamare, C. Catacchio, C. Alkan, G. Giannuzzi, F. Antonacci, M. Cardone, G. Della Valle, M. Malig, M. Rocchi, E. Eichler, M. Ventura. - In: MOLECULAR BIOLOGY AND EVOLUTION. - ISSN 0737-4038. - 26:8(2009), pp. 1889-1900. [10.1093/molbev/msp101]
New insights into centromere organization and evolution from the white-cheeked gibbon and marmoset
G. Giannuzzi;
2009
Abstract
All these data shed light on the evolution of the centromeric sequences in Primates. Our results suggest radical differences in the structure, organization, and evolution of alpha-satellite DNA among different primate species, supporting the notion that 1) all the centromeric sequence in Primates evolved by genomic amplification, unequal crossover, and sequence homogenization using a 171 bp monomer as the basic seeding unit and 2) centromeric function is linked to relatively short repeated elements, more than higher-order structure. Moreover, our data indicate that complex higher-order repeat structures are a peculiarity of the hominid lineage, showing the more complex organization in humans.File | Dimensione | Formato | |
---|---|---|---|
2009_Cellamare-Catacchio.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
754.62 kB
Formato
Adobe PDF
|
754.62 kB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.