All these data shed light on the evolution of the centromeric sequences in Primates. Our results suggest radical differences in the structure, organization, and evolution of alpha-satellite DNA among different primate species, supporting the notion that 1) all the centromeric sequence in Primates evolved by genomic amplification, unequal crossover, and sequence homogenization using a 171 bp monomer as the basic seeding unit and 2) centromeric function is linked to relatively short repeated elements, more than higher-order structure. Moreover, our data indicate that complex higher-order repeat structures are a peculiarity of the hominid lineage, showing the more complex organization in humans.
New insights into centromere organization and evolution from the white-cheeked gibbon and marmoset / A. Cellamare, C. Catacchio, C. Alkan, G. Giannuzzi, F. Antonacci, M. Cardone, G. Della Valle, M. Malig, M. Rocchi, E. Eichler, M. Ventura. - In: MOLECULAR BIOLOGY AND EVOLUTION. - ISSN 0737-4038. - 26:8(2009), pp. 1889-1900. [10.1093/molbev/msp101]
Titolo: | New insights into centromere organization and evolution from the white-cheeked gibbon and marmoset | |
Autori: | ||
Parole Chiave: | evolution; primates; centromere | |
Settore Scientifico Disciplinare: | Settore BIO/18 - Genetica | |
Data di pubblicazione: | 2009 | |
Rivista: | ||
Tipologia: | Article (author) | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1093/molbev/msp101 | |
Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
---|---|---|---|---|
2009_Cellamare-Catacchio.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |