Aims In degenerative mitral regurgitation (DMR), lack of mortality scores predicting death favours misperception of individual patients' risk and inappropriate decision-making. Methods and results The Mitral Regurgitation International Database (MIDA) registries include 3666 patients (age 66 ± 14 years; 70% males; follow-up 7.8 ± 5.0 years) with pure, isolated, DMR consecutively diagnosed by echocardiography at tertiary (European/North/South-American) centres. The MIDA Score was derived from the MIDA-Flail-Registry (2472 patients with DMR and flail leaflet-Derivation Cohort) by weighting all guideline-provided prognostic markers, and externally validated in the MIDA-BNP-Registry (1194 patients with DMR and flail leaflet/prolapse-Validation Cohort). The MIDA Score ranged from 0 to 12 depending on accumulating risk factors. In predicting total mortality post-diagnosis, the MIDA Score showed excellent concordance both in Derivation Cohort (c = 0.78) and Validation Cohort (c = 0.81). In the whole MIDA population (n = 3666 patients), 1-year mortality with Scores 0, 7-8, and 11-12 was 0.4, 17, and 48% under medical management and 1, 7, and 14% after surgery, respectively (P < 0.001). Five-year survival with Scores 0, 7-8, and 11-12 was 98 ± 1, 57 ± 4, and 21 ± 10% under medical management and 99 ± 1, 82 ± 2, and 57 ± 9% after surgery (P < 0.001). In models including all guideline-provided prognostic markers and the EuroScoreII, the MIDA Score provided incremental prognostic information (P < 0.002). Conclusion The MIDA Score may represent an innovative tool for DMR management, being able to position a given patient within a continuous spectrum of short- and long-term mortality risk, either under medical or surgical management. This innovative prognostic indicator may provide a specific framework for future clinical trials aiming to compare new technologies for DMR treatment in homogeneous risk categories of patients.
The MIDA Mortality Risk Score : Development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation / F. Grigioni, M.A. Clavel, J.L. Vanoverschelde, C. Tribouilloy, R. Pizarro, M. Huebner, J.F. Avierinos, A. Barbieri, R. Suri, A. Pasquet, D. Rusinaru, G.D. Gargiulo, P. Oberti, A. Thdron, F. Bursi, H. Michelena, S. Lazam, C. Szymanski, V.T. Nkomo, M. Schumacher, L. Bacchi-Reggiani, M. Enriquez-Sarano. - In: EUROPEAN HEART JOURNAL. - ISSN 0195-668X. - 39:15(2018), pp. 1281-1291. [10.1093/eurheartj/ehx465]
|Titolo:||The MIDA Mortality Risk Score : Development and external validation of a prognostic model for early and late death in degenerative mitral regurgitation|
|Parole Chiave:||Mitral regurgitation; Mitral repair; Percutaneous mitral repair; Percutaneous mitral replacement; Prognosis; Surgery|
|Settore Scientifico Disciplinare:||Settore MED/11 - Malattie dell'Apparato Cardiovascolare|
|Data di pubblicazione:||2018|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1093/eurheartj/ehx465|
|Appare nelle tipologie:||01 - Articolo su periodico|