IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca

IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.

AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.

MicroRNAs (miRNAs) play determinant roles in gene expression and several cellular processes of mammalian. These processes include differentiation, development, apoptosis, and cancer pathomechanisms. In detail, miRNAs are known to regulate the expression of keys genes relevant to cancer and potentially to other diseases [1-3]. MiRNAs are short noncoding RNAs having a central function in gene expression, since miRNAs are involved in cellular differentiation processes [4, 5], organism developments [6], and apoptosis. Furthermore, recent studies provide growing evidence of the contribution of miRNAs in cancer cellular mechanisms. Therefore, the analysis and the correct identification of miRNAs expression levels play a key role for better understanding and classifying cancer and other diseases. In parallel with the drastic growing of interest into the study of miRNAs, the support of systems and tools that allow an efficient and more robust analysis of miRNA's expression levels become increasing mandatory to have a better disease identification.

Analysis and clustering of MicroRNA array: A new efficient and reliable computational method / L. Sterpone, F. Collino, G. Camussi, C. Loconsole (ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY). - In: Software Tools and Algorithms for Biological Systems / [a cura di] H.R. Arabnia, Q.-N. Tran. - [s.l] : Springer-Verlag, 2011. - ISBN 9781441970459. - pp. 679-688 [10.1007/978-1-4419-7046-6_69]

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