Previous evidence suggests that sialic acid-binding Ig-like lectin 7 (Siglec-7) protein is significantly increased in patients with chronic hepatitis C virus (HCV) infection and directly correlates with clinical parameters of liver inflammation and fibrosis. The aim of this study was to determine the diagnostic value of Siglec-7 as a non-invasive tool to assess liver fibrosis in patients with chronic hepatitis C in a cross-sectional study. Serum levels of Siglec-7 were retrospectively tested in 1,007 consecutive patients with chronic HCV infection recruited at three different European sites and data examined by the "imperfect gold-standard" statistical analysis. Liver stiffness obtained by transient elastography (TE) was considered the standard reference. Liver fibrosis was staged according to published cut-offs of liver stiffness measurement by TE. Accuracy of detection of liver fibrosis stage was not increased by Siglec-7 alone. However, we developed a new index (SiGAP) including Siglec-7, γ-glutamyl transferase, age and platelet count which showed increased sensitivity and specificity in predicting fibrosis compared with APRI or FIB4 indices. The AUROC of SiGAP for the diagnosis of significant (≥ F2) and advanced liver fibrosis (≥ F3) showed significantly higher values than those of APRI and FIB-4. Siglec-7 may be useful as a complementary tool to assess liver fibrosis stage in patients with chronic hepatitis C when included in a specifically designed algorithm, which showed high level of accuracy in the detection of F2 and F3 fibrosis stage.

A new algorithm shows superior ability to discriminate liver fibrosis stages in chronic hepatitis C / S. Varchetta, D. Mele, R. D'Ambrosio, R. Perbellini, A. Lombardi, A. Rojas, S. Paolucci, F. Baldanti, B. Oliviero, S. Mantovani, C. Tinelli, A. De Silvestri, M. Romero Gomez, P. Lampertico, M.U. Mondelli. - In: JOURNAL OF VIRAL HEPATITIS. - ISSN 1352-0504. - (2021). [Epub ahead of print] [10.1111/jvh.13570]

A new algorithm shows superior ability to discriminate liver fibrosis stages in chronic hepatitis C

R. D'Ambrosio;R. Perbellini;A. Lombardi;P. Lampertico;
2021

Abstract

Previous evidence suggests that sialic acid-binding Ig-like lectin 7 (Siglec-7) protein is significantly increased in patients with chronic hepatitis C virus (HCV) infection and directly correlates with clinical parameters of liver inflammation and fibrosis. The aim of this study was to determine the diagnostic value of Siglec-7 as a non-invasive tool to assess liver fibrosis in patients with chronic hepatitis C in a cross-sectional study. Serum levels of Siglec-7 were retrospectively tested in 1,007 consecutive patients with chronic HCV infection recruited at three different European sites and data examined by the "imperfect gold-standard" statistical analysis. Liver stiffness obtained by transient elastography (TE) was considered the standard reference. Liver fibrosis was staged according to published cut-offs of liver stiffness measurement by TE. Accuracy of detection of liver fibrosis stage was not increased by Siglec-7 alone. However, we developed a new index (SiGAP) including Siglec-7, γ-glutamyl transferase, age and platelet count which showed increased sensitivity and specificity in predicting fibrosis compared with APRI or FIB4 indices. The AUROC of SiGAP for the diagnosis of significant (≥ F2) and advanced liver fibrosis (≥ F3) showed significantly higher values than those of APRI and FIB-4. Siglec-7 may be useful as a complementary tool to assess liver fibrosis stage in patients with chronic hepatitis C when included in a specifically designed algorithm, which showed high level of accuracy in the detection of F2 and F3 fibrosis stage.
Siglec-7; chronic hepatitis C; diagnosis; liver fibrosis
Settore MED/17 - Malattie Infettive
6-lug-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/855338
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