Metabolism is the central engine of living organisms as it provides energy and building blocks for many essential components of each cell, which are required for specific functions in different tissues. Mitochondria are the main site for energy production in living organisms and they also provide intermediate metabolites required for the synthesis of other biologically relevant molecules. Such cellular processes are finely tuned at different levels, including allosteric regulation, posttranslational modifications, and transcription of genes encoding key proteins in metabolic pathways. Peroxisome proliferator activated receptor ! coactivator 1 (PGC1) proteins are transcriptional coactivators involved in the regulation of many cellular processes, mostly ascribable to metabolic pathways. Here, we will discuss some aspects of the cellular processes regulated by PGC1s, bringing up some examples of their role in mitochondrial and cellular metabolism, and how metabolic regulation in mitochondria by members of the PGC1 family affects the immune system. We will analyze how PGC1 proteins are regulated at the transcriptional and posttranslational level and will also examine other regulators of mitochondrial metabolism and the related cellular functions, considering approaches to identify novel mitochondrial regulators and their role in physiology and disease. Finally, we will analyze possible therapeutical perspectives currently under assessment that are applicable to different disease states.

PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular Metabolism / L. Coppi, S. Ligorio, N. Mitro, D. Caruso, E.S.R. De Fabiani, M. Crestani. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1422-0067. - 22:13(2021 Jun 27), pp. 6913.1-6913.11. [10.3390/ijms22136913]

PGC1s and Beyond: Disentangling the Complex Regulation of Mitochondrial and Cellular Metabolism

L. Coppi
Co-primo
;
S. Ligorio
Co-primo
;
N. Mitro;D. Caruso;E.S.R. De Fabiani
;
M. Crestani
2021-06-27

Abstract

Metabolism is the central engine of living organisms as it provides energy and building blocks for many essential components of each cell, which are required for specific functions in different tissues. Mitochondria are the main site for energy production in living organisms and they also provide intermediate metabolites required for the synthesis of other biologically relevant molecules. Such cellular processes are finely tuned at different levels, including allosteric regulation, posttranslational modifications, and transcription of genes encoding key proteins in metabolic pathways. Peroxisome proliferator activated receptor ! coactivator 1 (PGC1) proteins are transcriptional coactivators involved in the regulation of many cellular processes, mostly ascribable to metabolic pathways. Here, we will discuss some aspects of the cellular processes regulated by PGC1s, bringing up some examples of their role in mitochondrial and cellular metabolism, and how metabolic regulation in mitochondria by members of the PGC1 family affects the immune system. We will analyze how PGC1 proteins are regulated at the transcriptional and posttranslational level and will also examine other regulators of mitochondrial metabolism and the related cellular functions, considering approaches to identify novel mitochondrial regulators and their role in physiology and disease. Finally, we will analyze possible therapeutical perspectives currently under assessment that are applicable to different disease states.
mitochondria; metabolic regulation; mitochondrial disorders
Settore BIO/10 - Biochimica
Control of metabolic and inflammatory pathways by nuclear receptor
Dipartimenti di Eccellenza 2018-2022 - Dipartimento di SCIENZE FARMACOLOGICHE E BIOMOLECOLARI
Health and Understanding of Metabolism, Aging and Nutrition
Histone deacetylase 3 in adipose tissue: a link between immuno-metabolic dysfunctions and obesity and type 2 diabetes
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/853738
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