Objective: This study examined neurophysiological (NI), split-hand (SI) and split-leg (SLI) index in patients with amyotrophic lateral sclerosis (ALS), and their correlation with functional status, disease duration, staging and survival. Methods: Eighty-two patients underwent nerve conduction study to analyze NI, SI and SLI. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R), disease progression rate (AFS), Milano Torino (MiToS) and King & rsquo;s staging systems, Forced Vital Capacity (FVC), and survival data were collected. Results: Both NI and SI indices were significantly associated with ALSFRS-R, MiToS, King & rsquo;s and FVC. Slow progressor patients (AFS < 0.5) reported a significantly higher NI and SI values compared to both normal (0.5 < AFS < 1.00) and fast progressors (AFS > 1.0). After dichotomizing patients in slow progressors (AFS < 0.5) and not-slow progressors (AFS > 0.5), a combination of SI index and disease duration revealed to be the best prediction model to discriminate patients in accordance with their disease progression (c index: 0.92), leading to a new prognostic index: the & lsquo;Split-Hand prognostic index & rsquo; (SHpi). Conclusion: SI and NI are correlated with functional status and FVC. SHpi index could represent an useful tool to discriminate patients in accordance with their disease progression. Significance: These data provide novel evidence of neurophysiological indices as promising biomarkers in ALS.

Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression / A. Barp, A. Lizio, F. Gerardi, C. Tarlarini, M. Luca, V. Sansone, C. Lunetta. - In: CLINICAL NEUROPHYSIOLOGY. - ISSN 1872-8952. - 132:7(2021), pp. 1564-1571. [10.1016/j.clinph.2021.02.394]

Neurophysiological indices in amyotrophic lateral sclerosis correlate with functional outcome measures, staging and disease progression

C. Tarlarini;V. Sansone;
2021

Abstract

Objective: This study examined neurophysiological (NI), split-hand (SI) and split-leg (SLI) index in patients with amyotrophic lateral sclerosis (ALS), and their correlation with functional status, disease duration, staging and survival. Methods: Eighty-two patients underwent nerve conduction study to analyze NI, SI and SLI. Amyotrophic Lateral Sclerosis Functional Rating Scale-Revised (ALSFRS-R), disease progression rate (AFS), Milano Torino (MiToS) and King & rsquo;s staging systems, Forced Vital Capacity (FVC), and survival data were collected. Results: Both NI and SI indices were significantly associated with ALSFRS-R, MiToS, King & rsquo;s and FVC. Slow progressor patients (AFS < 0.5) reported a significantly higher NI and SI values compared to both normal (0.5 < AFS < 1.00) and fast progressors (AFS > 1.0). After dichotomizing patients in slow progressors (AFS < 0.5) and not-slow progressors (AFS > 0.5), a combination of SI index and disease duration revealed to be the best prediction model to discriminate patients in accordance with their disease progression (c index: 0.92), leading to a new prognostic index: the & lsquo;Split-Hand prognostic index & rsquo; (SHpi). Conclusion: SI and NI are correlated with functional status and FVC. SHpi index could represent an useful tool to discriminate patients in accordance with their disease progression. Significance: These data provide novel evidence of neurophysiological indices as promising biomarkers in ALS.
Amyotrophic lateral sclerosis; Split-hand index; Neurophysiological index; Split-leg index; Prognosis; Prediction model
Settore MED/26 - Neurologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/853337
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