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IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishC-peptide therapy protects against diabetic micro- and macrovascular damages and neuropatic complications. However, to date, the role of C-peptide in preventing diabetes-related bone loss has not been investigated. Our aim was to evaluate if C-peptide infusion improves bone quality in diabetic rats. Twenty-three male Wistar rats were randomly divided into three groups: normal control group; sham diabetic control group; diabetic plus C-peptide group. Diabetes was induced by streptozotocin injection and C-peptide was delivered subcutaneously for 6 weeks. We performed micro-CT and histological testing to assess several trabecular microarchitectural parameters. At the end, diabetic plus C-peptide rats had a higher serum C-peptide (p = 0.02) and calcium (p = 0.04) levels and tibia weight (p = 0.02) than the diabetic control group. The diabetic plus C-peptide group showed a higher trabecular thickness and cross-sectional thickness than the diabetic control group (p = 0.01 and p = 0.03). Both the normal control and diabetic plus C-peptide groups had more Runx-2 and PLIN1 positive cells in comparison with the diabetic control group (p = 0.045 and p = 0.034). Diabetic rats receiving C-peptide had higher quality of trabecular bone than diabetic rats not receiving this treatment. If confirmed, C-peptide could have a role in improving bone quality in diabetes.
Effects of C-Peptide Replacement Therapy on Bone Microarchitecture Parameters in Streptozotocin-Diabetic Rats / S. Maurotti, C. Russo, V. Musolino, S. Nucera, M. Gliozzi, M. Scicchitano, F. Bosco, V.M. Morittu, M. Ragusa, E. Mazza, R. Pujia, C. Gazzaruso, D. Britti, M.T. Valenti, M. Deiana, S. Romeo, S. Giannini, L. Dalle Carbonare, V. Mollace, A. Pujia, T. Montalcini. - In: CALCIFIED TISSUE INTERNATIONAL. - ISSN 0171-967X. - 107:3(2020), pp. 266-280. [10.1007/s00223-020-00716-0]
| Titolo: | Effects of C-Peptide Replacement Therapy on Bone Microarchitecture Parameters in Streptozotocin-Diabetic Rats | |
| Autori: | ||
| Parole Chiave: | c-peptide; Bone microarchitectural parameters; Type 1 diabetes mellitus; Osteoporosis; Diabetic rat model | |
| Settore Scientifico Disciplinare: | Settore MED/13 - Endocrinologia | |
| Data di pubblicazione: | 2020 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s00223-020-00716-0 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
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| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| 2020 Calcified Tissue International.pdf | Publisher's version/PDF | Open Access Visualizza/Apri |
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