Background: Limited and wide-ranging data are available on the recurrent Clostridioides difficile infection (rCDI) incidence rate. Methods: We performed a cohort study with the aim to assess the incidence of and risk factors for rCDI. Adult patients with a first CDI, hospitalized in 15 Italian hospitals, were prospectively included and followed-up for 30 d after the end of antimicrobial treatment for their first CDI. A case-control study was performed to identify risk factors associated with 30-day onset rCDI. Results: Three hundred nine patients with a first CDI were included in the study; 32% of the CDI episodes (99/309) were severe/complicated; complete follow-up was available for 288 patients (19 died during the first CDI episode, and 2 were lost during follow-up). At the end of the study, the crude all-cause mortality rate was 10.7% (33 deaths/309 patients). Two hundred seventy-one patients completed the follow-up; rCDI occurred in 21% of patients (56/271) with an incidence rate of 72/10,000 patient-days. Logistic regression analysis identified exposure to cephalosporin as an independent risk factor associated with rCDI (RR: 1.7; 95% CI: 1.1-2.7, p = 0.03). Conclusion: Our study confirms the relevance of rCDI in terms of morbidity and mortality and provides a reliable estimation of its incidence.
Prospective Study on Incidence, Risk Factors and Outcome of Recurrent Clostridioides difficile Infections / G. Granata, N. Petrosillo, L. Adamoli, M. Bartoletti, A. Bartoloni, G. Basile, M. Bassetti, P. Bonfanti, R. Borromeo, G. Ceccarelli, A.M. De Luca, S. Di Bella, S. Fossati, E. Franceschini, I. Gentile, D.R. Giacobbe, E. Giacometti, F. Ingrassia, F. Lagi, G. Lobreglio, A. Lombardi, L.I. Lupo, R. Luzzati, A.E. Maraolo, M. Mikulska, M.U. Mondelli, A. Mularoni, C. Mussini, A. Oliva, A. Pandolfo, C. Rogati, F.F. Trapani, M. Venditti, P. Viale, E. Caraffa, M.A. Cataldo. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:5(2021 Feb 19), pp. 1127.1-1127.11. [10.3390/JCM10051127]
Prospective Study on Incidence, Risk Factors and Outcome of Recurrent Clostridioides difficile Infections
A. LombardiMembro del Collaboration Group
;
2021
Abstract
Background: Limited and wide-ranging data are available on the recurrent Clostridioides difficile infection (rCDI) incidence rate. Methods: We performed a cohort study with the aim to assess the incidence of and risk factors for rCDI. Adult patients with a first CDI, hospitalized in 15 Italian hospitals, were prospectively included and followed-up for 30 d after the end of antimicrobial treatment for their first CDI. A case-control study was performed to identify risk factors associated with 30-day onset rCDI. Results: Three hundred nine patients with a first CDI were included in the study; 32% of the CDI episodes (99/309) were severe/complicated; complete follow-up was available for 288 patients (19 died during the first CDI episode, and 2 were lost during follow-up). At the end of the study, the crude all-cause mortality rate was 10.7% (33 deaths/309 patients). Two hundred seventy-one patients completed the follow-up; rCDI occurred in 21% of patients (56/271) with an incidence rate of 72/10,000 patient-days. Logistic regression analysis identified exposure to cephalosporin as an independent risk factor associated with rCDI (RR: 1.7; 95% CI: 1.1-2.7, p = 0.03). Conclusion: Our study confirms the relevance of rCDI in terms of morbidity and mortality and provides a reliable estimation of its incidence.File | Dimensione | Formato | |
---|---|---|---|
jcm-10-01127.pdf
accesso aperto
Tipologia:
Publisher's version/PDF
Dimensione
1.33 MB
Formato
Adobe PDF
|
1.33 MB | Adobe PDF | Visualizza/Apri |
Pubblicazioni consigliate
I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.