Bayesian Network Integrated Testing Strategy and beyond

In a recent series of papers written by Jaworska with different coauthors, compelling reasons for adopting a probabilistic approach to Integrated Testing Strategies were detailed. In a case study on skin sensitization, a Bayesian Network proved to be effective in adapting testing strategies to the available evidence. There is no doubt that probabilistic Integrated Testing Strategies are one way to pursue the goals of 3Rs effectively; nevertheless, some issues deserve further comment to pinpoint statistical criticalities and to widen the methodological perspective towards Bayesian graphical models.