Multiple Sclerosis (MS) is a chronic and potentially highly disabling disease that can cause permanent damage and deterioration of the central nervous system. In Europe it is the leading cause of non-traumatic disabilities in young adults, since more than 700,000 EU people suffer from MS. Although recent studies on MS pathophysiology have been performed, providing interesting results, MS remains a challenging disease. In this context, thanks to recent advances in software and hardware technologies, computational models and computer simulations are becoming appealing research tools to support scientists in the study of such disease. Motivated by this consideration, we propose in this paper a new model to study the evolution of MS in silico, and the effects of the administration of the daclizumab drug, taking into account also spatiality and temporality of the involved phenomena. Moreover, we show how the intrinsic symmetries of the model we have developed can be exploited to drastically reduce the complexity of its analysis.
Multiple sclerosis disease: A computational approach for investigating its drug interactions / S. Pernice, M. Beccuti, G. Romano, M. Pennisi, A. Maglione, S. Cutrupi, F. Pappalardo, L. Capra, G. Franceschinis, M. De Pierro, G. Balbo, F. Cordero, R. Calogero (LECTURE NOTES IN ARTIFICIAL INTELLIGENCE). - In: Computational Intelligence Methods for Bioinformatics and Biostatistics / [a cura di] P. Cazzaniga, D. Besozzi, I. Merelli, L. Manzoni. - Prima edizione. - [s.l] : Springer Science, 2020. - ISBN 9783030630607. - pp. 299-308 (( Intervento presentato al 16. convegno CIBB tenutosi a Bergamo nel 2019.
Titolo: | Multiple sclerosis disease: A computational approach for investigating its drug interactions | |
Autori: | ||
Parole Chiave: | Colored Petri Nets; Computational model; Multiple Sclerosis | |
Settore Scientifico Disciplinare: | Settore INF/01 - Informatica | |
Data di pubblicazione: | 2020 | |
Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/978-3-030-63061-4_26 | |
Tipologia: | Book Part (author) | |
Appare nelle tipologie: | 03 - Contributo in volume |
File in questo prodotto:
File | Descrizione | Tipologia | Licenza | |
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CIBB2019_3D_RRMS (1).pdf | Post-print, accepted manuscript ecc. (versione accettata dall'editore) | Administrator Richiedi una copia | ||
Pernice2020_Chapter_MultipleSclerosisDiseaseACompu.pdf | Publisher's version/PDF | Administrator Richiedi una copia |