The main goal in developing peptidomimetics is the stabilization of the bioactive conformation of peptides. Among all the secondary structures, turns are of paramount importance. This review highlights the recent advances in the design and synthesis of cyclic turn mimics. Both amino acids, carbo- and hetero-cyclic scaffolds have been considered focusing on their use in the preparation of peptidomimetics and on their ability to induce to induce alpha-, beta- and gamma-turns.

Fishing in the Toolbox of Cyclic Turn Mimics: a Literature Overview of the Last Decade / R. Bucci, F. Foschi, C. Loro, E. Erba, M.L. Gelmi, S. Pellegrino. - In: EUROPEAN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1434-193X. - 2021:20(2021 May 26), pp. 2887-2900. [10.1002/ejoc.202100244]

Fishing in the Toolbox of Cyclic Turn Mimics: a Literature Overview of the Last Decade

R. Bucci
Primo
;
E. Erba;M.L. Gelmi
Penultimo
;
S. Pellegrino
Ultimo
2021-05-26

Abstract

The main goal in developing peptidomimetics is the stabilization of the bioactive conformation of peptides. Among all the secondary structures, turns are of paramount importance. This review highlights the recent advances in the design and synthesis of cyclic turn mimics. Both amino acids, carbo- and hetero-cyclic scaffolds have been considered focusing on their use in the preparation of peptidomimetics and on their ability to induce to induce alpha-, beta- and gamma-turns.
Peptidomimetics; Non-natural amino acids; Heterocycles; Carbocycles; Secondary Structure Mimics;
Settore CHIM/06 - Chimica Organica
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/848707
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