Magnesium (Mg) is essential to skeletal muscle where it plays a key role in myofiber relaxation. Although the importance of Mg in the mature skeletal muscle is well established, little is known about the role of Mg in myogenesis. We studied the effects of low and high extracellular Mg in C2C12 myogenic differentiation. Non-physiological Mg concentrations induce oxidative stress in myoblasts. The increase of reactive oxygen species, which occurs during the early phase of the differentiation process, inhibits myoblast membrane fusion, thus impairing myogenesis. Therefore, correct Mg homeostasis, also maintained through a correct dietary intake, is essential to assure the regenerative capacity of skeletal muscle fibers.

Magnesium influences membrane fusion during myogenesis by modulating oxidative stress in c2c12 myoblasts / M. Zocchi, D. Bechet, A. Mazur, J. Maier, S. Castiglioni. - In: NUTRIENTS. - ISSN 2072-6643. - 13:4(2021), pp. 1049.1-1049.8. [10.3390/nu13041049]

Magnesium influences membrane fusion during myogenesis by modulating oxidative stress in c2c12 myoblasts

M. Zocchi
Primo
;
J. Maier
Penultimo
;
S. Castiglioni
Ultimo
2021

Abstract

Magnesium (Mg) is essential to skeletal muscle where it plays a key role in myofiber relaxation. Although the importance of Mg in the mature skeletal muscle is well established, little is known about the role of Mg in myogenesis. We studied the effects of low and high extracellular Mg in C2C12 myogenic differentiation. Non-physiological Mg concentrations induce oxidative stress in myoblasts. The increase of reactive oxygen species, which occurs during the early phase of the differentiation process, inhibits myoblast membrane fusion, thus impairing myogenesis. Therefore, correct Mg homeostasis, also maintained through a correct dietary intake, is essential to assure the regenerative capacity of skeletal muscle fibers.
magnesium; myogenesis; oxidative stress; membrane fusion
Settore MED/04 - Patologia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/848521
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