Inflammatory Bowel Diseases (IBDs) are gastrointestinal disorders characterized by chronic, relapsing inflammation, with growing incidence worldwide over the last decades and distinctive features in the pediatric age. An increasing body of evidence indicates that gut microbiota plays a major role in inflammatory disorders, including IBDs. In this review we will discuss the most recent evidences on dysbiotic changes associated with gut inflammation, as well as environmental and genetic factors contributing to IBD pathogenesis, with a focus on the peculiarities of the pediatric age.

IBDs and the pediatric age: Their peculiarities and the involvement of the microbiota / L. Cococcioni, S. Panelli, I. Varotto Boccazzi, D. Di Carlo, D. Pistone, G. Leccese, G.V. Zuccotti, F. Comandatore. - In: DIGESTIVE AND LIVER DISEASE. - ISSN 1590-8658. - 53:1(2021 Jan 01), pp. 17-25.

IBDs and the pediatric age: Their peculiarities and the involvement of the microbiota

L. Cococcioni
Primo
;
S. Panelli
Secondo
;
I. Varotto Boccazzi;D. Di Carlo;D. Pistone;G. Leccese;G.V. Zuccotti
Penultimo
;
F. Comandatore
Ultimo
2021-01-01

Abstract

Inflammatory Bowel Diseases (IBDs) are gastrointestinal disorders characterized by chronic, relapsing inflammation, with growing incidence worldwide over the last decades and distinctive features in the pediatric age. An increasing body of evidence indicates that gut microbiota plays a major role in inflammatory disorders, including IBDs. In this review we will discuss the most recent evidences on dysbiotic changes associated with gut inflammation, as well as environmental and genetic factors contributing to IBD pathogenesis, with a focus on the peculiarities of the pediatric age.
Crohn's disease; IBD; Microbiota; Pediatrics; Ulcerative colitis
Settore BIO/19 - Microbiologia Generale
11-nov-2020
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/848180
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