Background: The prevention and treatment of obesity and its cardio-metabolic complications are relevant issues worldwide. Among lifestyle approaches, very low-calorie ketogenic diets (VLCKD) have been shown to lead to rapid initial weight loss, resulting in better long-term weight loss maintenance. As no information on VLCKD studies carried on in a real-world setting are available, we conducted this multi-centre study in a real-world setting, aiming at assessing the efficacy and the safety of a specific multiphasic VLCKD program in women with overweight or obesity. Methods: A multi-center, prospective, uncontrolled trial was conducted in 33 outpatient women (age range 27–60 y) with overweight or obesity (BMI: 30.9 ± 2.7 kg/m2; waist circumference: 96.0 ± 9.4 cm) who started a VLCKD dietary program (duration: 24 weeks), divided into four phases. The efficacy of VLCKD was assessed by evaluating anthropometric measures and cardiometabolic markers; liver and kidney function biomarkers were assessed as safety parameters. Results: The VLCKD program resulted in a significant decrease of body weight and BMI (−14.6%) and waist circumference (−12.4%). At the end of the protocol, 33.3% of the participants reached a normal weight and the subjects in the obesity range were reduced from 70% to 16.7%. HOMA-IR was markedly reduced from 3.17 ± 2.67 to 1.73 ± 1.23 already after phase 2 and was unchanged thereafter. Systolic blood pressure decreased after phase 1 (−3.5 mmHg) and remained unchanged until the end of the program. Total and LDL cholesterol and triglycerides were significantly reduced by VLCKD along with a significant HDL cholesterol increase. Liver, kidney and thyroid function markers did not change and remained within the reference range. Conclusions: The findings of a multi-center VLCKD program conducted in a real-world setting in a cohort of overweight/obese women indicate that it is safe and effective, as it results in a major improvement of cardiometabolic parameters, thus leading to benefits that span well beyond the mere body weight/adiposity reduction.
Reduction of cardio-metabolic risk and body weight through a multiphasic very-low calorie ketogenic diet program in women with overweight/obesity: A study in a real-world setting / E. Tragni, L. Vigna, M. Ruscica, C. Macchi, M. Casula, A. Santelia, A.L. Catapano, P. Magni. - In: NUTRIENTS. - ISSN 2072-6643. - 13:6(2021 May 26), pp. 1804.1804-1804.1817.
|Titolo:||Reduction of cardio-metabolic risk and body weight through a multiphasic very-low calorie ketogenic diet program in women with overweight/obesity: A study in a real-world setting|
TRAGNI, ELENA CLELIA GIUSEPPINA (Primo) [Membro del Collaboration Group]
VIGNA, LUISELLA (Secondo)
CATAPANO, ALBERICO LUIGI (Penultimo)
MAGNI, PAOLO (Ultimo) (Corresponding)
|Parole Chiave:||Cardiovascular risk; Insulin resistance; Nutraceutical; Obesity; Very-low calorie ketogenic diet|
|Settore Scientifico Disciplinare:||Settore MED/04 - Patologia Generale|
Settore MED/13 - Endocrinologia
Settore MED/49 - Scienze Tecniche Dietetiche Applicate
Settore MED/05 - Patologia Clinica
|Data di pubblicazione:||26-mag-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/nu13061804|
|Appare nelle tipologie:||01 - Articolo su periodico|