Chronic kidney disease (CKD) is characterized by the retention of solutes named uremic toxins, which strongly associate with high morbidity and mortality. Mounting evidence suggests that targeting uremic toxins and/or their pathways may decrease the risk of cardiovascular disease in CKD patients. Dialysis therapies have been developed to improve removal of uremic toxins. Advances in our understanding of uremic retention solutes as well as improvements in dialysis membranes and techniques (HDx, Expanded Hemodialysis) will offer the opportunity to ameliorate clinical symptoms and outcomes, facilitate personalized and targeted dialysis treatment, and improve quality of life, morbidity and mortality.

Expanded Haemodialysis as a Current Strategy to Remove Uremic Toxins / P. Ciceri, M. Cozzolino. - In: TOXINS. - ISSN 2072-6651. - 13:6(2021), pp. 380.1-380.14. [10.3390/toxins13060380]

Expanded Haemodialysis as a Current Strategy to Remove Uremic Toxins

M. Cozzolino
Ultimo
2021

Abstract

Chronic kidney disease (CKD) is characterized by the retention of solutes named uremic toxins, which strongly associate with high morbidity and mortality. Mounting evidence suggests that targeting uremic toxins and/or their pathways may decrease the risk of cardiovascular disease in CKD patients. Dialysis therapies have been developed to improve removal of uremic toxins. Advances in our understanding of uremic retention solutes as well as improvements in dialysis membranes and techniques (HDx, Expanded Hemodialysis) will offer the opportunity to ameliorate clinical symptoms and outcomes, facilitate personalized and targeted dialysis treatment, and improve quality of life, morbidity and mortality.
uremic toxins; chronic kidney disease; cardiovascular disease; vascular calcification; dialysis
Settore MED/14 - Nefrologia
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/847799
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