IRIS Institutional Research Information System - AIR Archivio Istituzionale della Ricerca
IRIS è il sistema di gestione integrata dei dati della ricerca (persone, progetti, pubblicazioni, attività) adottato dall'Università degli Studi di Milano.
AIR nasce in UNIMI nel 2006 con lo scopo di raccogliere, documentare e conservare le informazioni sulla produzione scientifica dell'Università degli Studi di Milano e costituisce di fatto l'Anagrafe della ricerca dell'Ateneo.
EnglishPurposeBreast cancer (BC) is a leading cause of morbidity, disability, and mortality in women, worldwide; triple-negative BC (TNBC) is a subtype traditionally associated with poorer prognosis. TNBC special histology subtypes present distinct clinical and molecular features and sensitivity to antineoplastic treatments. However, no consensus has been defined on the best adjuvant therapy. The aim of the review is to study the evidence from literature to inform the choice of adjuvant treat-ments in this setting.MethodsWe systematically searched literature assessing the benefit of adjuvant chemotherapy in patients with TNBC special histotypes (PROSPERO: CRD42020153818).ResultsWe screened 6404 records (15 included). All the studies estimated the benefit of different chemotherapy regimens, in retrospective cohorts (median size: 69 patients (range min–max: 17–5142); median follow-up: 51 months (range: 21–268); mostly in Europe and USA). In patients with early-stage adenoid cystic TNBC, a marginal role of chemotherapy was reported. Similar for apocrine TNBC. Medullary tumors exhibited an intrinsic good prognosis with a limited role of chemotherapy, suggested to be modulated by the presence of tumor-infiltrating lymphocytes. A significant impact of chemotherapy on the overall survival was estimated in patients with metaplastic TNBC. Limitations were related to the retrospective design of all the studies and heterogeneous treatments received by the patients.ConclusionsThere is potential opportunity to consider treatment de-escalation and less intense therapies in some patients with early, special histology-type TNBC. International efforts are indispensable to validate prospective clinical decision models.
Benefit of adjuvant chemotherapy in patients with special histology subtypes of triple-negative breast cancer : a systematic review / D. Trapani, F. Giugliano, J. Uliano, V.A.A. Zia, A. Marra, G. Viale, E. Ferraro, A. Esposito, C. Criscitiello, P. D'amico, G. Curigliano. - In: BREAST CANCER RESEARCH AND TREATMENT. - ISSN 0167-6806. - 187:2(2021 Jun), pp. 323-337.
| Titolo: | Benefit of adjuvant chemotherapy in patients with special histology subtypes of triple-negative breast cancer : a systematic review | |
| Autori: | TRAPANI, DARIO (Primo) GIUGLIANO, FEDERICA (Secondo) | |
| Parole Chiave: | Adjuvant treatment intensity customization; Escalation and de-escalation; Special histology; Triple-negative breast cancer; WHO classification; | |
| Settore Scientifico Disciplinare: | Settore MED/06 - Oncologia Medica | |
| Data di pubblicazione: | giu-2021 | |
| Rivista: | ||
| Tipologia: | Article (author) | |
| Data ahead of print / Data di stampa: | 27-mag-2021 | |
| Digital Object Identifier (DOI): | http://dx.doi.org/10.1007/s10549-021-06259-8 | |
| Appare nelle tipologie: | 01 - Articolo su periodico |
File in questo prodotto:
| File | Descrizione | Tipologia | Licenza | |
|---|---|---|---|---|
| Triple Negative Subtype Curigliano 2021.pdf | Post-print, accepted manuscript ecc. (versione accettata dall'editore) | Embargo: 27/05/2022 Richiedi una copia | ||
| Trapani2021_Article_BenefitOfAdjuvantChemotherapyI.pdf | Publisher's version/PDF | Administrator Richiedi una copia | ||
| Trapani2021_Article_BenefitOfAdjuvantChemotherapyI.pdf | Publisher's version/PDF | Administrator Richiedi una copia |
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