We found this particular case during the course of a clinical trial designed to assess the pharmacokinetics of oral prednisone in normal and diseased children. The plasma concentrations of prednisone, its main metabolite prednisolone, and endogenous cortisol were measured by HPLC at selected times during 8-h periods starting at 7:30 a.m. One 9.9-year-old administered prednisone 0.5 mg/kg p.o. was found to be hypothyroid (TSH: 351 μIU/mL; fT4: <2 pg/mL; fT3: <1 pg/mL); four age-matched normal boys (aged 6.6 ± 4.9 years) served as a control group. In comparison with the controls, the hypothyroid boy showed a marked increase in the total AUC of prednisone (3360 μg h/L versus 215 ± 83 μg h/L) and prednisolone (4040 μg h/L versus 724 ± 77 μg h/L), and an altered pattern of endogenous cortisol, which is known to be impaired in hypothyroid subjects. After 6 months of thyroxine replacement therapy (75 μg/day), the AUCs of prednisone and prednisolone returned to normal values (prednisone: 248 μg h/L; prednisolone: 528 μg h/L), as did the pattern of circadian cortisol secretion. In conclusion, our data indicate that the pharmacokinetics of prednisone and prednisolone can be profoundly altered by hypothyroidism, and subsequently restored by thyroxine replacement therapy.

Pharmacokinetics of prednisone and prednisolone in a case of hypothyroidism: effect of replacement therapy / S. Bergamaschi, R. Rusconi, M. Gervasoni, A.E. Rigamonti, S.G. Cella, S.R. Bareggi. - In: STEROIDS. - ISSN 0039-128X. - 70:11(2005 Oct), pp. 787-789.

Pharmacokinetics of prednisone and prednisolone in a case of hypothyroidism: effect of replacement therapy

S. Bergamaschi
Primo
;
R. Rusconi
Secondo
;
M. Gervasoni;A.E. Rigamonti;S.G. Cella
Penultimo
;
S.R. Bareggi
Ultimo
2005-10

Abstract

We found this particular case during the course of a clinical trial designed to assess the pharmacokinetics of oral prednisone in normal and diseased children. The plasma concentrations of prednisone, its main metabolite prednisolone, and endogenous cortisol were measured by HPLC at selected times during 8-h periods starting at 7:30 a.m. One 9.9-year-old administered prednisone 0.5 mg/kg p.o. was found to be hypothyroid (TSH: 351 μIU/mL; fT4: <2 pg/mL; fT3: <1 pg/mL); four age-matched normal boys (aged 6.6 ± 4.9 years) served as a control group. In comparison with the controls, the hypothyroid boy showed a marked increase in the total AUC of prednisone (3360 μg h/L versus 215 ± 83 μg h/L) and prednisolone (4040 μg h/L versus 724 ± 77 μg h/L), and an altered pattern of endogenous cortisol, which is known to be impaired in hypothyroid subjects. After 6 months of thyroxine replacement therapy (75 μg/day), the AUCs of prednisone and prednisolone returned to normal values (prednisone: 248 μg h/L; prednisolone: 528 μg h/L), as did the pattern of circadian cortisol secretion. In conclusion, our data indicate that the pharmacokinetics of prednisone and prednisolone can be profoundly altered by hypothyroidism, and subsequently restored by thyroxine replacement therapy.
Children; Cortisol; Hypothiroidism; Pharmacokinetics; Prednisolone
Settore BIO/14 - Farmacologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/8470
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