The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated. © 2011 Elsevier Inc.

Anaplastic large-cell lymphoma / G. Inghirami, S.A.C.C.R. Pileri, G. Cuccuru, G. Inghirami, B. Martinoglio, E. Medico, E. Pellegrino, R. Piva, M.L. Ruberto, A. Fornari, D. Novero, M. Chilosi, A. Zamó, F. Facchetti, S. Lonardi, A. De Chiara, F. Fulciniti, C. Doglioni, M. Ponzoni, L. Agnelli, A. Neri, K. Todoerti, C. Agostinelli, P.P. Piccaluga, S. Pileri, B. Falini, E. Tiacci, P. Van Loo, T. Tousseyn, C. De Wolf-Peeters, E. Geissinger, H.K. Muller-Hermelink, A. Rosenwald, M.A. Piris, E. Rodriguez M.. - In: SEMINARS IN DIAGNOSTIC PATHOLOGY. - ISSN 0740-2570. - 28:3(2011 Aug), pp. 190-201. [10.1053/j.semdp.2011.03.002]

Anaplastic large-cell lymphoma

L. Agnelli;A. Neri;K. Todoerti;
2011-08

Abstract

The concept of anaplastic large-cell lymphoma (ALCL) has changed over the years because of a stream of new information and novel understanding regarding the cell of origin, biology, genetics, and clinical features of these neoplasms. This new information has led to the current classification proposed by the expert reviewers of the World Health Organization. The objective of this review is to present the most updated information on the cytologic and histologic features of these entities, with a special reference to diagnostic algorithms. A detailed description of the genetic aberrations and the pathogenetic mechanisms leading to transformation is presented. The clinical features of ALCL and novel tailored strategies are briefly illustrated. © 2011 Elsevier Inc.
Anaplastic large-cell lymphoma (ALCL); Anaplastic lymphoma kinase (ALK); Chimeric fusion proteins; Immunohistochemistry; Molecular biology; Peripheral T-cell lymphoma (PTCL); Phenotype; Signaling pathways; Targeted therapy
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/845609
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