The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), recently described as early marker of different infections. PSP secretion has been shown to be associated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infection and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.
Clinical application of presepsin as diagnostic biomarker of infection: overview and updates / E. Galliera, L. Massaccesi, E. de Vecchi, G. Banfi, M.M.C. Romanelli. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1437-4331. - 58:1(2020), pp. 11-17.
|Titolo:||Clinical application of presepsin as diagnostic biomarker of infection: overview and updates|
GALLIERA, EMANUELA RITA (Primo) (Corresponding)
MASSACCESI, LUCA (Secondo)
CORSI ROMANELLI, MASSIMILIANO MARCO (Ultimo)
|Parole Chiave:||bacterial infection; presepsin; serum marker|
|Settore Scientifico Disciplinare:||Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio|
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore MED/05 - Patologia Clinica
|Data di pubblicazione:||2020|
|Data ahead of print / Data di stampa:||17-ago-2019|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1515/cclm-2019-0643|
|Appare nelle tipologie:||01 - Articolo su periodico|