The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), recently described as early marker of different infections. PSP secretion has been shown to be associated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infection and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates / E. Galliera, L. Massaccesi, E. de Vecchi, G. Banfi, M.M.C. Romanelli. - In: CLINICAL CHEMISTRY AND LABORATORY MEDICINE. - ISSN 1437-4331. - 58:1(2020), pp. 11-17.

Clinical application of presepsin as diagnostic biomarker of infection: overview and updates

Galliera, Emanuela;Massaccesi, Luca;de Vecchi, Elena;Romanelli, Massimiliano M. Corsi
2020

Abstract

The appropriate identification of bacterial infection is the basis for effective treatment and control of infective disease. Among this context, an emerging biomarker of infection is presepsin (PSP), recently described as early marker of different infections. PSP secretion has been shown to be associated with monocyte phagocytosis and plasmatic levels of PSP increase in response to bacterial infection and decrease after antibiotic treatment, therefore it can be considered a marker of activation of immune cell response towards an invading pathogen. Different methods have been developed to measure PSP and this review will briefly describe the different clinical fields of application of PSP, ranging from intensive care to neonatal infection, to orthopedic and pulmonary infection as well as fungal infections and cardiovascular infections.
bacterial infection; presepsin; serum marker
Settore MED/46 - Scienze Tecniche di Medicina di Laboratorio
Settore MED/07 - Microbiologia e Microbiologia Clinica
Settore MED/05 - Patologia Clinica
17-ago-2019
CLINICAL CHEMISTRY AND LABORATORY MEDICINE
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/845438
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