Pediatric obesity remains a challenge in modern society. Recently, research has focused on the role of the brown adipose tissue (BAT) as a potential target of intervention. In this review, we revised preclinical and clinical works on factors that may promote BAT or browning of white adipose tissue (WAT) from fetal age to adolescence. Maternal lifestyle, type of breastfeeding and healthy microbiota can affect the thermogenic activity of BAT. Environmental factors such as exposure to cold or physical activity also play a role in promoting and activating BAT. Most of the evidence is preclinical, although in clinic there is some evidence on the role of omega-3 PUFAs (EPA and DHA) supplementation on BAT activation. Clinical studies are needed to dissect the early factors and their modulation to allow proper BAT development and functions and to prevent onset of childhood obesity.
Brown adipose tissue : new challenges for prevention of childhood obesity. A narrative review / E. Verduci, V. Calcaterra, E. Di Profio, G. Fiore, F. Rey, V.C. Magenes, C.F. Todisco, S. Carelli, G.V. Zuccotti. - In: NUTRIENTS. - ISSN 2072-6643. - 13:5(2021 Apr 24), pp. 1450.1-1450.27.
|Titolo:||Brown adipose tissue : new challenges for prevention of childhood obesity. A narrative review|
VERDUCI, ELVIRA (Corresponding)
CARELLI, STEFANA (Corresponding)
|Parole Chiave:||breastfeeding; brown adipose tissue; browning of white adipose tissue; childhood obesity; docosahexaenoic acid; eicosapentaenoic acid; fetal programming; gut microbiota|
|Settore Scientifico Disciplinare:||Settore MED/38 - Pediatria Generale e Specialistica|
|Data di pubblicazione:||24-apr-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/nu13051450|
|Appare nelle tipologie:||01 - Articolo su periodico|