Muscle maintenance relies on a multidimensional biologic balance that is extremely delicate in breast cancer patients, particularly those with advanced-stage disease. The biology that underpins breast cancer tumorigenesis, tumor progression and response to pharmacotherapies can modify muscle homeostasis, resulting in volumetric muscle loss. This condition dramatically increases the overall patients’ frailty, leading to reduced survival and impaired quality of life. Physical activity may potentially improve muscle health in these patients, providing that an optimal patients selection is performed. The understanding of volumetric muscle loss biology in breast cancer survivors, coupled with focused clinical studies, would allow for the implementation of individualized rehabilitation protocols.

Understanding the biology of volumetric muscle loss for an individualized exercise rehabilitation approach in breast cancer patients / M. Invernizzi, K. Venetis, E. Sajjadi, R. Piciotti, A. de Sire, N. Fusco. - In: CURRENT OPINION IN PHARMACOLOGY. - ISSN 1471-4892. - 58(2021), pp. 27-34.

Understanding the biology of volumetric muscle loss for an individualized exercise rehabilitation approach in breast cancer patients

K. Venetis
Co-primo
;
E. Sajjadi;R. Piciotti;N. Fusco
Ultimo
2021

Abstract

Muscle maintenance relies on a multidimensional biologic balance that is extremely delicate in breast cancer patients, particularly those with advanced-stage disease. The biology that underpins breast cancer tumorigenesis, tumor progression and response to pharmacotherapies can modify muscle homeostasis, resulting in volumetric muscle loss. This condition dramatically increases the overall patients’ frailty, leading to reduced survival and impaired quality of life. Physical activity may potentially improve muscle health in these patients, providing that an optimal patients selection is performed. The understanding of volumetric muscle loss biology in breast cancer survivors, coupled with focused clinical studies, would allow for the implementation of individualized rehabilitation protocols.
Settore MED/08 - Anatomia Patologica
Settore MED/34 - Medicina Fisica e Riabilitativa
Article (author)
File in questo prodotto:
File Dimensione Formato  
[2021] [COPHAR] VML_1-s2.0-S1471489221000278-main.pdf

accesso riservato

Tipologia: Publisher's version/PDF
Dimensione 608.5 kB
Formato Adobe PDF
608.5 kB Adobe PDF   Visualizza/Apri   Richiedi una copia
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/842344
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 4
  • ???jsp.display-item.citation.isi??? 4
social impact