Objective. The purpose of this study was to assess vestibular findings and clinical history in a large cohort of patients affected by Ménière’s disease. Methods. We retrospectively analysed 511 adult patients fulfilling criteria for definite unilateral Ménière’s disease according to Barany Society. Thorough clinical history, audiomet-ric exam, central nervous system MRI, quantification of serum autoantibodies and complete vestibular function test were performed. Results. Mean age at clinical record was 55.4 years, while age at onset of the first vertigo attack was 47.4 ± 14.3 years. Ménière’s disease overlapped with migraine in 43.4% of patients. In 31.7% of cases, positivity was found for at least one autoantibody. Forty-nine patients (9.6%) had family history for Ménière’s disease. Bedside examination resulted in 14.7% positivity for video head impulse test, 58.9% for skull vibration-induced nystagmus, 38.7% for the positional test and 23.1% for the post head shaking test. Complete negative examination was reported in 115 cases. Conclusions. Ménière’s disease was seen to present a characteristic phenotypic pattern in our cohort, confirming the crucial role of thorough anamnesis and bedside examination in diagnosis.

Evaluation of a large cohort of adult patients with ménière’s disease : Bedside and clinical history / R. Teggi, R.A. Battista, F. Di Berardino, M. Familiari, I. Cangiano, O. Gatti, M. Bussi. - In: ACTA OTORHINOLARYNGOLOGICA ITALICA. - ISSN 0392-100X. - 40:6(2020 Dec), pp. 444-449.

Evaluation of a large cohort of adult patients with ménière’s disease : Bedside and clinical history

F. Di Berardino;
2020

Abstract

Objective. The purpose of this study was to assess vestibular findings and clinical history in a large cohort of patients affected by Ménière’s disease. Methods. We retrospectively analysed 511 adult patients fulfilling criteria for definite unilateral Ménière’s disease according to Barany Society. Thorough clinical history, audiomet-ric exam, central nervous system MRI, quantification of serum autoantibodies and complete vestibular function test were performed. Results. Mean age at clinical record was 55.4 years, while age at onset of the first vertigo attack was 47.4 ± 14.3 years. Ménière’s disease overlapped with migraine in 43.4% of patients. In 31.7% of cases, positivity was found for at least one autoantibody. Forty-nine patients (9.6%) had family history for Ménière’s disease. Bedside examination resulted in 14.7% positivity for video head impulse test, 58.9% for skull vibration-induced nystagmus, 38.7% for the positional test and 23.1% for the post head shaking test. Complete negative examination was reported in 115 cases. Conclusions. Ménière’s disease was seen to present a characteristic phenotypic pattern in our cohort, confirming the crucial role of thorough anamnesis and bedside examination in diagnosis.
Autoimmunity; Family history; Migraine; Ménière’s disease; Vestibular function tests
Settore MED/32 - Audiologia
Settore MED/31 - Otorinolaringoiatria
16-lug-2020
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/842330
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