Deep eutectic solvents (DESs) have gained attention as green and safe as well as economically and environmentally sustainable alternative to the traditional organic solvents. Here, we report the combination of an atom-economic, very convenient and inexpensive reagent, such as BH3NH3, with bio-based eutectic mixtures as biorenewable solvents in the synthesis of nitroalkanes, valuable precursors of amines. A variety of nitrostyrenes and alkyl-substituted nitroalkenes, including α- and β-substituted nitroolefins, were chemoselectively reduced to the nitroalkanes, with an atom economy-oriented, simple and convenient experimental procedure. A reliable and easily reproducible protocol to isolate the product without the use of any organic solvent was established, and the recyclability of the DES mixture was successfully investigated.
Nitroalkene reduction in deep eutectic solvents promoted by BH3NH3 / C. Faverio, M.F. Boselli, P. Camarero Gonzalez, A. Puglisi, M. Benaglia. - In: BEILSTEIN JOURNAL OF ORGANIC CHEMISTRY. - ISSN 1860-5397. - 17(2021 May 06), pp. 1041-1047.
|Titolo:||Nitroalkene reduction in deep eutectic solvents promoted by BH3NH3|
BENAGLIA, MAURIZIO (Corresponding)
|Parole Chiave:||alternative solvents; atom economy; DES; nitro derivatives; reduction|
|Settore Scientifico Disciplinare:||Settore CHIM/06 - Chimica Organica|
|Progetto:||Enabling TECHNOlogies-driven chemistry: a tailored TRAINing research program for batch and flow synthesis of chiral amino derivatives (TECHNOTRAIN)|
|Data di pubblicazione:||6-mag-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3762/bjoc.17.83|
|Appare nelle tipologie:||01 - Articolo su periodico|