Theragnostic agents are often used for combining diagnostic and therapeutic approaches. In the last decade, many anticancer compounds bearing both these features were realized using transition metal complexes. In particular, platinum(II) complexes were synthetized considering the possibility to module the electronic and steric features. Recently, we studied two different classes of charged platinum(II) compounds, a positive[1] and a negative charged [2] respectively, characterized by the presence of different types of labile ligands able to amplify the liphofilicity of the compounds, as testified by their major internalization into the cells. Moreover, these classes of anticancer agents have recently emerged for their unconventional mechanisms of action compared to cisplatin-like drugs, their potent cytotoxic activity and their distinctive anticancer spectrum of action. Considering these different aspects, a matching between these classes was realized affording neutral complexes reavealing as good candidates for their anticytotoxic and antiproliferative activities against the orphan triple negative breast cancer (specifically toward resistant MDA-MB-31 cancer cell line).

Theragnostic neutral Pt(II) complexes based on 8-aminoquinoline skeleton / I. Rimoldi, G. Facchetti, M.G. Lupo, N. Ferri. ((Intervento presentato al 20. convegno BioMet : Workshop on Pharmacobiometallics tenutosi a online nel 2021.

Theragnostic neutral Pt(II) complexes based on 8-aminoquinoline skeleton

I. Rimoldi
;
G. Facchetti;
2021

Abstract

Theragnostic agents are often used for combining diagnostic and therapeutic approaches. In the last decade, many anticancer compounds bearing both these features were realized using transition metal complexes. In particular, platinum(II) complexes were synthetized considering the possibility to module the electronic and steric features. Recently, we studied two different classes of charged platinum(II) compounds, a positive[1] and a negative charged [2] respectively, characterized by the presence of different types of labile ligands able to amplify the liphofilicity of the compounds, as testified by their major internalization into the cells. Moreover, these classes of anticancer agents have recently emerged for their unconventional mechanisms of action compared to cisplatin-like drugs, their potent cytotoxic activity and their distinctive anticancer spectrum of action. Considering these different aspects, a matching between these classes was realized affording neutral complexes reavealing as good candidates for their anticytotoxic and antiproliferative activities against the orphan triple negative breast cancer (specifically toward resistant MDA-MB-31 cancer cell line).
Settore CHIM/03 - Chimica Generale e Inorganica
Settore BIO/14 - Farmacologia
Consorzio Interuniversitario di Ricerca in Chimica dei Metalli nei Sistemi Biologici (CIRCMSB)
Theragnostic neutral Pt(II) complexes based on 8-aminoquinoline skeleton / I. Rimoldi, G. Facchetti, M.G. Lupo, N. Ferri. ((Intervento presentato al 20. convegno BioMet : Workshop on Pharmacobiometallics tenutosi a online nel 2021.
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/841821
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