A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log10 diminution in 15 min. Conversely, H2O2 solutions with no additives displayed a scarce virucidal activity (1.1 log10 diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H2O2-based disinfectant active against the novel coronavirus.

Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents? / D. Mileto, A. Mancon, F. Staurenghi, A. Rizzo, S. Econdi, M.R. Gismondo, M. Guidotti. - In: JOURNAL OF CHEMICAL HEALTH AND SAFETY. - ISSN 1871-5532. - (2021). [Epub ahead of print] [10.1021/acs.chas.0c00095]

Inactivation of SARS-CoV-2 in the Liquid Phase: Are Aqueous Hydrogen Peroxide and Sodium Percarbonate Efficient Decontamination Agents?

D. Mileto;A. Mancon;A. Rizzo;S. Econdi;M.R. Gismondo;
2021

Abstract

A diluted 3% w/w hydrogen peroxide solution acidified to pH 2.5 by adding citric acid inactivated SARS-CoV-2 virus by more than 4 orders of magnitude in 5 min. After a contact time of 15 min, no viral replication was detected. Aqueous solutions of sodium percarbonate inactivated coronavirus by >3 log10 diminution in 15 min. Conversely, H2O2 solutions with no additives displayed a scarce virucidal activity (1.1 log10 diminution in 5 min), confirming that a pH-modifying ingredient is necessary to have a H2O2-based disinfectant active against the novel coronavirus.
COVID-19; SARS-CoV-2; hydrogen peroxide; sodium percarbonate; biocidal agents; chemical inactivation; disinfection; virucidal solutions
Settore CHIM/04 - Chimica Industriale
Settore BIO/10 - Biochimica
Settore MED/07 - Microbiologia e Microbiologia Clinica
16-feb-2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/840725
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