The prevalence and the factors related to cytomegalovirus (CMV) disease (CMVd) during the 1st year of renal transplantation (RTx) and the relationship between CMVd and early and long-term graft and RTx-patient (RTx-p) survival were evaluated. In 505 RTx-p, followed up for 8(5-11) years, data were recorded after 1-(T1) and 12-(T12) months of RTx. CMVd was defined either by CMV replication without clinical signs of disease (CMVr, 43%), or CMV replication with signs of disease (CMVs, 57%). During the 1st year of RTx, 45% of RTx-p had CMVd (CMVd+). CMVd+ patients were older than CMVd- patients. Female gender and Donor CMV-IgG+ (CMV IgG-D+)/recipient IgG- (CMV IgG-R-) status were more prevalent in CMVd+. At T1, CMVd+ had lower albumin, haemoglobin, and higher uric-acid and reactive C-protein than CMVd- and, at T1 and T12, received more steroids. Albumin-T1 was the unique factor in determining CMVd+, maintaining its significance also after the inclusion of IgG-D+/IgG-R- status to the model. CMVs had higher prevalence of CMV IgG-D+/IgG-R- than CMVr. CMVd, CMVr, and CMVs had no impact on graft loss (11% of RTx-p) and RTx-p death (8% of RTx-p). CMVd is highly prevalent during the 1st year of RTx. Albumin-T1 influences CMVd insurgence. CMVd did not impact on RTx and RTx-p loss.
Cytomegalovirus Disease in Renal Transplanted Patients : Prevalence, Determining Factors, and Influence on Graft and Patients Outcomes / C.M. Alfieri, P. Molinari, M. Gandolfo, M. Campise, D. Cresseri, A. Regalia, E. Favi, M. Li, M. Ikehata, S. Delbue, P. Messa. - In: PATHOGENS. - ISSN 2076-0817. - 10:4(2021 Apr 14), pp. 473.1-473.15.
|Titolo:||Cytomegalovirus Disease in Renal Transplanted Patients : Prevalence, Determining Factors, and Influence on Graft and Patients Outcomes|
ALFIERI, CARLO MARIA (Corresponding)
|Parole Chiave:||albumin; cytomegalovirus; graft outcome; infection; renal transplantation|
|Settore Scientifico Disciplinare:||Settore MED/14 - Nefrologia|
|Data di pubblicazione:||14-apr-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/pathogens10040473|
|Appare nelle tipologie:||01 - Articolo su periodico|