To assess the risk of mother-to-infant transmission of hepatitis C virus (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom 22 were coinfected with HIV and 94 had HCV alone. None of the babies whose mothers had HCV alone acquired HCV, while 8 babies (36%; p<0·001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV and HIV (3). There was no association between any specific maternal HCV genotype and enhanced risk of neonatal infection. HCV-RNA levels were significantly higher (p<0·05) in mothers with HIV coinfection than in those with HCV alone. These data indicate that maternal HIV status correlates with enhanced level of viraemia which favours neonatal infection.

Mother-to-infant transmission of hepatitis C virus / A.R. Zanetti, S. Paccagnini, N. Principi, G. Pizzocolo, M.L. Caccamo, E.D. Amico, G. Cambie, L. Vecchi. - In: THE LANCET. - ISSN 0140-6736. - 345:8945(1995), pp. 289-291. [10.1016/S0140-6736(95)90277-5]

Mother-to-infant transmission of hepatitis C virus

A.R. Zanetti;S. Paccagnini;N. Principi;
1995

Abstract

To assess the risk of mother-to-infant transmission of hepatitis C virus (HCV), we followed up 116 babies of anti-HCV positive mothers, of whom 22 were coinfected with HIV and 94 had HCV alone. None of the babies whose mothers had HCV alone acquired HCV, while 8 babies (36%; p<0·001) of mothers co-infected with HIV acquired HCV (5 babies) or HCV and HIV (3). There was no association between any specific maternal HCV genotype and enhanced risk of neonatal infection. HCV-RNA levels were significantly higher (p<0·05) in mothers with HIV coinfection than in those with HCV alone. These data indicate that maternal HIV status correlates with enhanced level of viraemia which favours neonatal infection.
Settore MED/42 - Igiene Generale e Applicata
1995
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/838611
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