Thyroid cancer (TC) is the most common endocrine malignancy. Recent progress in thyroid cancer biology revealed a certain degree of intratumoral heterogeneity, highlighting the coexistence of cellular subpopulations with distinct proliferative capacities and differentiation abilities. Among those subpopulations, cancer stem-like cells (CSCs) are hypothesized to drive TC heterogeneity, contributing to its metastatic potential and therapy resistance. CSCs principally exist in tumor areas with specific microenvironmental conditions, the so-called stem cell niches. In particular, in thyroid cancer, CSCs' survival is enhanced in the hypoxic niche, the immune niche, and some areas with specific extracellular matrix composition. In this review, we summarize the current knowledge about thyroid CSCs, the tumoral niches that allow their survival, and the implications for TC therapy.
Thyroid Cancer Stem-Like Cells: From Microenvironmental Niches to Therapeutic Strategies / E.S. Grassi, V. Ghiandai, L. Persani. - In: JOURNAL OF CLINICAL MEDICINE. - ISSN 2077-0383. - 10:7(2021 Apr 01).
|Titolo:||Thyroid Cancer Stem-Like Cells: From Microenvironmental Niches to Therapeutic Strategies|
GRASSI, ELISA STELLARIA (Primo) (Corresponding)
GHIANDAI, VIOLA (Secondo)
PERSANI, LUCA (Ultimo)
|Parole Chiave:||thyroid cancer; cancer stem cells; tumor microenvironment; CSCs niche; targeted therapy|
|Settore Scientifico Disciplinare:||Settore MED/13 - Endocrinologia|
Settore MED/06 - Oncologia Medica
|Data di pubblicazione:||1-apr-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/jcm10071455|
|Appare nelle tipologie:||01 - Articolo su periodico|