Lipidomics is a lipid-targeted metabolomics approach that aims to the comprehensive analysis of lipids in biological systems in order to highlight the specific functions of lipid species in health and disease. Lipids play pivotal roles as they are major structural components of the cellular membranes and energy storage molecules but also, as most recently shown, they act as functional and regulatory components of intra-and intercellular signaling. Herein, emphasis is given to the recently highlighted roles of specific bioactive lipids species, as polyunsaturated fatty acids (PUFA)-derived mediators (generally known as eicosanoids), endocannabinoids (eCBs), and lysophospholipids (LPLs), and their involvement in the mesenchymal stem cells (MSCs)-related inflammatory scenario. Indeed, MSCs are a heterogenous population of multipotent cells that have attracted much attention for their potential in regulating inflammation, immunomodulatory capabilities, and reparative roles. The lipidomics of the inflammatory disease osteoarthritis (OA) and the influence of MSCs-derived lipids have also been addressed.

Bioactive lipids inMSCs biology : State of the art and role in inflammation / S. Casati, C. Giannasi, S. Niada, R.F. Bergamaschi, M. Orioli, A.T. Brini. - In: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. - ISSN 1661-6596. - 22:3(2021), pp. 1481.1-1481.19. [10.3390/ijms22031481]

Bioactive lipids inMSCs biology : State of the art and role in inflammation

Casati S.;Giannasi C.;Niada S.;Orioli M.;Brini A. T.
2021

Abstract

Lipidomics is a lipid-targeted metabolomics approach that aims to the comprehensive analysis of lipids in biological systems in order to highlight the specific functions of lipid species in health and disease. Lipids play pivotal roles as they are major structural components of the cellular membranes and energy storage molecules but also, as most recently shown, they act as functional and regulatory components of intra-and intercellular signaling. Herein, emphasis is given to the recently highlighted roles of specific bioactive lipids species, as polyunsaturated fatty acids (PUFA)-derived mediators (generally known as eicosanoids), endocannabinoids (eCBs), and lysophospholipids (LPLs), and their involvement in the mesenchymal stem cells (MSCs)-related inflammatory scenario. Indeed, MSCs are a heterogenous population of multipotent cells that have attracted much attention for their potential in regulating inflammation, immunomodulatory capabilities, and reparative roles. The lipidomics of the inflammatory disease osteoarthritis (OA) and the influence of MSCs-derived lipids have also been addressed.
Bioactive lipids; Inflammation; Lipidomics; Mesenchymal stem cells; Osteoarthritis; Adaptive Immunity; Animals; Cell Differentiation; Eicosanoids; Endocannabinoids; Extracellular Vesicles; Fatty Acids, Unsaturated; Humans; Immunity, Innate; Inflammation; Lipids; Lysophospholipids; Mesenchymal Stem Cell Transplantation; Mesenchymal Stem Cells; Osteoarthritis
Settore BIO/14 - Farmacologia
Settore CHIM/08 - Chimica Farmaceutica
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/838361
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