Wound healing is a multistep regeneration process that requires immunological and microenvironmental conditions occurring simultaneously. Since platelets and their granules play a pivotal role in wound healing, their use as medication is extensively been evaluated in several fields, spacing from chronic wounds to aesthetics. In this chapter, we focused on wound healing and specifically on the contribution exerted by platelet-rich plasma (PRP) in different wounds. We performed a comprehensive literature review, including randomized clinical trials, prospective studies, case--control, and case series, to investigate clinical long-term outcomes (>12 months) of topical PRP. Our results suggest that PRP improves healing, sustaining a faster tissue regeneration, reducing scar formation, improving neo-vascularization, and decreasing recurrences. Remarkably, patients display lower pain and discomfort resulting in an increased satisfaction. Since this effective technique is ideal to be performed in hospital as well as in private practice, authors encourage the use of PRP in all patients with wounds, both chronic and acute.

Platelet-Rich Plasma for Wound Healing / M. Del Fabbro, S. Panda, G. Damiani, R.R.Z. Conic, S. Taschieri, P.D.M. Pigatto - In: Platelet-Rich Plasma in Dermatologic Practice / [a cura di] N.S. Sadick. - [s.l] : Springer, 2021. - ISBN 9783030662295. - pp. 45-70 [10.1007/978-3-030-66230-1_4]

Platelet-Rich Plasma for Wound Healing

M. Del Fabbro;S. Panda;G. Damiani;S. Taschieri;P.D.M. Pigatto
2021

Abstract

Wound healing is a multistep regeneration process that requires immunological and microenvironmental conditions occurring simultaneously. Since platelets and their granules play a pivotal role in wound healing, their use as medication is extensively been evaluated in several fields, spacing from chronic wounds to aesthetics. In this chapter, we focused on wound healing and specifically on the contribution exerted by platelet-rich plasma (PRP) in different wounds. We performed a comprehensive literature review, including randomized clinical trials, prospective studies, case--control, and case series, to investigate clinical long-term outcomes (>12 months) of topical PRP. Our results suggest that PRP improves healing, sustaining a faster tissue regeneration, reducing scar formation, improving neo-vascularization, and decreasing recurrences. Remarkably, patients display lower pain and discomfort resulting in an increased satisfaction. Since this effective technique is ideal to be performed in hospital as well as in private practice, authors encourage the use of PRP in all patients with wounds, both chronic and acute.
Wounds; Burns; Platelet-rich plasma; Platelets Wound healing; Tissue regeneration; Platelet; Long-term outcomes; Patient’s satisfaction
Settore MED/35 - Malattie Cutanee e Veneree
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/837843
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