Cigarette smoking is a major independent risk factor for cardiovascular diseases (CVD). The underlying mechanisms, however, are not clearly understood. Lungs are the primary route of exposure to smoke, with pulmonary cells and surfactant being the first structures directly exposed, resulting in the leakage of the immature proteoform of surfactant protein B (proSP‐B). Herein, we evaluated whether proSP‐B joined the cargo of high‐density lipoprotein (HDL) proteins in healthy young subjects (n = 106) without any CVD risk factor other than smoking, and if HDL‐associated proSP‐B (HDL‐SPB) correlated with pulmonary function parameters, systemic inflammation, and oxidative stress. At univariable analysis, HDL‐SPB resulted significantly higher in smokers (2.2‐ fold, p < 0.001) than in non‐smokers. No significant differences have been detected between smokers and non‐smokers for inflammation, oxidation variables, and alveolar‐capillary diffusion markers. In a multivariable model, HDL‐SPB was independently associated with smoking. In conclusion, HDL‐SPB is not only a precocious and sensitive index of the acute effects of smoke, but it might be also a potential causal factor in the onset of the vascular damage induced by modified HDL. These findings contribute to the emerging concept that the quality of the HDL proteome, rather than the quantity of particles, plays a central role in CVD risk protection.

Immature circulating SP-B, bound to HDL, represents an early sign of smoke-induced pathophysiological alterations / C. Banfi, M. Brioschi, M. Mapelli, E. Gianazza, A. Mallia, B. Zoanni, E. Salvioni, P. Gugliandolo, N. Capra, F. Veglia, P. Agostoni. - In: BIOMOLECULES. - ISSN 2218-273X. - 11:4(2021 Apr 09), pp. 551.1-551.10. [10.3390/biom11040551]

Immature circulating SP-B, bound to HDL, represents an early sign of smoke-induced pathophysiological alterations

C. Banfi
Co-primo
;
M. Brioschi
Co-primo
;
M. Mapelli
Secondo
;
B. Zoanni;E. Salvioni;F. Veglia;P. Agostoni
Ultimo
2021-04-09

Abstract

Cigarette smoking is a major independent risk factor for cardiovascular diseases (CVD). The underlying mechanisms, however, are not clearly understood. Lungs are the primary route of exposure to smoke, with pulmonary cells and surfactant being the first structures directly exposed, resulting in the leakage of the immature proteoform of surfactant protein B (proSP‐B). Herein, we evaluated whether proSP‐B joined the cargo of high‐density lipoprotein (HDL) proteins in healthy young subjects (n = 106) without any CVD risk factor other than smoking, and if HDL‐associated proSP‐B (HDL‐SPB) correlated with pulmonary function parameters, systemic inflammation, and oxidative stress. At univariable analysis, HDL‐SPB resulted significantly higher in smokers (2.2‐ fold, p < 0.001) than in non‐smokers. No significant differences have been detected between smokers and non‐smokers for inflammation, oxidation variables, and alveolar‐capillary diffusion markers. In a multivariable model, HDL‐SPB was independently associated with smoking. In conclusion, HDL‐SPB is not only a precocious and sensitive index of the acute effects of smoke, but it might be also a potential causal factor in the onset of the vascular damage induced by modified HDL. These findings contribute to the emerging concept that the quality of the HDL proteome, rather than the quantity of particles, plays a central role in CVD risk protection.
inflammation; oxidative stress; smoke; surfactant protein B
Settore MED/11 - Malattie dell'Apparato Cardiovascolare
Article (author)
File in questo prodotto:
File Dimensione Formato  
biomolecules-11-00551-v2.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 871.31 kB
Formato Adobe PDF
871.31 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/837429
Citazioni
  • ???jsp.display-item.citation.pmc??? 1
  • Scopus 1
  • ???jsp.display-item.citation.isi??? 1
social impact