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The amyloidoses constitute a group of diseases occurring in humans and animals that are characterized by abnormal deposits of aggregated proteins in organs, affecting their structure and function. In the Abyssinian cat breed, a familial form of renal amyloidosis has been described. In this study, multi-omics analyses were applied and integrated to explore some aspects of the unknown pathogenetic processes in cats. Whole-genome sequences of two affected Abyssinians and 195 controls of other breeds (part of the 99 Lives initiative) were screened to prioritize potential disease-associated variants. Proteome and miRNAome from formalin-fixed paraffin-embedded kidney specimens of fully necropsied Abyssinian cats, three affected and three non-amyloidosis-affected were characterized. While the trigger of the disorder remains unclear, overall, (i) 35,960 genomic variants were detected; (ii) 215 and 56 proteins were identified as exclusive or overexpressed in the affected and control kidneys, respectively; (iii) 60 miRNAs were differentially expressed, 20 of which are newly described. With omics data integration, the general conclusions are: (i) the familial amyloid renal form in Abyssinians is not a simple monogenic trait; (ii) amyloid deposition is not triggered by mutated amyloidogenic proteins but is a mix of proteins codified by wild-type genes; (iii) the form is biochemically classifiable as AA amyloidosis.

Multi‑omic analyses in Abyssinian cats with primary renal amyloid deposits / F. Genova, S. Nonnis, E.M. Maffioli, G. Tedeschi, M.G. Strillacci, M. Carisetti, G. Sironi, F. Anna Cupaioli, N. Di Nanni, A. Mezzelani, E. Mosca, C.R. Helps, P.A.J. Leegwater, L. Dorso, M.L. Longeri. - In: SCIENTIFIC REPORTS. - ISSN 2045-2322. - 11:1(2021 Apr 16), pp. 8339.1-8339.14.

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