Human papillomavirus infection is a cause of the development of invasive cervical cancer. Three types of vaccine are currently available to prevent precancerous/cancerous lesions due to persistent infection, which is supported mainly by 7 different high-risk genotypes. The aim of this pilot study was to acquire preliminary data on type-specific prevalence 10 years after the implementation of the HPV vaccination program in Italy, in order to subsequently plan appropriate observational studies in the Italian population. First-voided urine samples were collected from 393 consenting subjects, both females and males, aged 18-40 years, and HPV DNA was detected by PCR amplification of a 450 bp L1 fragment. All amplified products were genotyped by means of the Restriction Fragment Length Polymorphism (RFLP) method. The female population was divided into three cohorts (“vaccine-eligible”, “pre-screening” and “screening” cohorts) according to the preventive intervention scheduled by age; males were included in the same three cohorts according to their year of birth. The overall prevalence of HPV infection was 19%, being higher in females than in males (22.1% vs. 13.6%, p = 0.03729). In the female population, 10 years after the start of the national immunization program, we observed a reduction in the prevalence of vaccine types and the number of circulating genotypes, especially in the “vaccine-eligible” cohort. The frequency of HPV vaccine types increased with age, particularly in males in the “pre-screening” and “screening” cohorts. Our study highlights the importance of monitoring HPV infection in both genders, to validate the effect of the HPV vaccination program.
HPV Type-Specific Prevalence a Decade after the Implementation of the Vaccination Program: Results from a Pilot Study / C. Fappani, S. Bianchi, D. Panatto, F. Petrelli, D. Colzani, S. Scuri, M. Gori, A. Amendola, I. Grappasonni, E. Tanzi, D. Amicizia. - In: VACCINES. - ISSN 2076-393X. - 9:4(2021), pp. 336.1-336.10.
|Titolo:||HPV Type-Specific Prevalence a Decade after the Implementation of the Vaccination Program: Results from a Pilot Study|
BIANCHI, SILVIA (Co-primo) [Conceptualization] (Corresponding)
|Parole Chiave:||HPV infection; urine samples; HPV genotype distribution; vaccine-preventable diseases; Italy|
|Settore Scientifico Disciplinare:||Settore MED/42 - Igiene Generale e Applicata|
Settore MED/07 - Microbiologia e Microbiologia Clinica
|Data di pubblicazione:||2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/vaccines9040336|
|Appare nelle tipologie:||01 - Articolo su periodico|