Considering the mechanisms capable of causing brain alterations in COVID-19, we aimed to study the occurrence of cognitive abnormalities in the months following hospital discharge. We recruited 38 (aged 22-74 years; 27 males) patients hospitalized for complications of SARS-CoV-2 infection in nonintensive COVID units. Participants underwent neuropsychological testing about 5 months after hospital discharge. Of all patients, 42.1% had processing speed deficits, while 26.3% showed delayed verbal recall deficits. Twenty-one percent presented with deficits in both processing speed and verbal memory. Bivariate analysis revealed a positive correlation between the lowest arterial oxygen partial pressure (PaO2) to fractional inspired oxygen (FiO2) (P/F) ratio during hospitalization and verbal memory consolidation performance (SRT-LTS score, r = 0.404, p = 0.027), as well as a positive correlation between SpO2 levels upon hospital arrival and delayed verbal recall performance (SRT-D score, rs = 0.373, p = 0.042). Acute respiratory distress syndrome (ARDS) during hospitalization was associated with worse verbal memory performance (ARDS vs. no ARDS: SRT-LTS mean score = 30.63 ± 13.33 vs. 44.50 ± 13.16, p = 0.007; SRT-D mean score = 5.95 ± 2.56 vs. 8.10 ± 2.62, p = 0.029). Cognitive abnormalities can frequently be found in COVID-19 patients 5 months after hospital discharge. Increased fatigability, deficits of concentration and memory, and overall decreased cognitive speed months after hospital discharge can interfere with work and daily activities.
Long-lasting cognitive abnormalities after COVID-19 / R. Ferrucci, M. Dini, E. Groppo, C. Rosci, M.R. Reitano, F. Bai, B. Poletti, A. Brugnera, V. Silani, A.D. Monforte, A. Priori. - In: BRAIN SCIENCES. - ISSN 2076-3425. - 11:2(2021 Feb), pp. 235.1-235.11.
|Titolo:||Long-lasting cognitive abnormalities after COVID-19|
FERRUCCI, ROBERTA (Primo)
DINI, MICHELANGELO (Secondo)
PRIORI, ALBERTO (Ultimo) (Corresponding)
|Parole Chiave:||Acute respiratory distress syndrome; Cognition; COVID-19; Processing speed;|
|Settore Scientifico Disciplinare:||Settore MED/26 - Neurologia|
Settore M-PSI/08 - Psicologia Clinica
|Data di pubblicazione:||feb-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.3390/brainsci11020235|
|Appare nelle tipologie:||01 - Articolo su periodico|