Background The brain of sheep has primarily been used in neuroscience as an animal model because of its similarity to the human brain, in particular if compared to other models such as the lissencephalic rodent brain. Their brain size also makes sheep an ideal model for the development of neurosurgical techniques using conventional clinical CT/MRI scanners and stereotactic systems for neurosurgery. Methods In this study, we present the design and validation of a new CT/MRI compatible head frame for the ovine model and software, with its assessment under two real clinical scenarios. Results Ex-vivo and in vivo trial results report an average linear displacement of the ovine head frame during conventional surgical procedures of 0.81 mm for ex-vivo trials and 0.68 mm for in vivo tests, respectively. Conclusions These trial results demonstrate the robustness of the head frame system and its suitability to be employed within a real clinical setting.

Development and in‐vivo assessment of a novel MRI‐Compatible headframe system for the ovine animal model / M. Trovatelli, S. Brizzola, D.D. Zani, A. Castellano, P. Mangili, M. Riva, M. Woolley, D. Johnson, F. Rodriguez y Baena, L. Bello, A. Falini, R. Secoli. - In: THE INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY. - ISSN 1478-5951. - 17:4(2021 Aug), pp. 1-11. [10.1002/rcs.2257]

Development and in‐vivo assessment of a novel MRI‐Compatible headframe system for the ovine animal model

Trovatelli, Marco;Brizzola, Stefano;Zani, Davide Danilo;Castellano, Antonella;Riva, Marco;Bello, Lorenzo;
2021-08

Abstract

Background The brain of sheep has primarily been used in neuroscience as an animal model because of its similarity to the human brain, in particular if compared to other models such as the lissencephalic rodent brain. Their brain size also makes sheep an ideal model for the development of neurosurgical techniques using conventional clinical CT/MRI scanners and stereotactic systems for neurosurgery. Methods In this study, we present the design and validation of a new CT/MRI compatible head frame for the ovine model and software, with its assessment under two real clinical scenarios. Results Ex-vivo and in vivo trial results report an average linear displacement of the ovine head frame during conventional surgical procedures of 0.81 mm for ex-vivo trials and 0.68 mm for in vivo tests, respectively. Conclusions These trial results demonstrate the robustness of the head frame system and its suitability to be employed within a real clinical setting.
animal model; invivo trial; MR‐; compatible headframe; neurosurgery; ovine model
Settore VET/09 - Clinica Chirurgica Veterinaria
Enhanced Delivery Ecosystem for Neurosurgery in 2020
H20_RIA16LBELL_M - Enhanced Delivery Ecosystem for Neurosurgery in 2020 - BELLO, LORENZO - H20_RIA - Horizon 2020_Research & Innovation Action/Innovation Action - 2015
4-apr-2021
THE INTERNATIONAL JOURNAL OF MEDICAL ROBOTICS AND COMPUTER ASSISTED SURGERY
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/831711
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