Objectives: Hysteresis of the respiratory system pressure-volume curve is related to alveolar surface forces, lung stress relaxation, and tidal reexpansion/collapse. Hysteresis has been suggested as a means of assessing lung recruitment. The objective of this study was to determine the relationship between hysteresis, mechanical characteristics of the respiratory system, and lung recruitment assessed by a CT scan in mechanically ventilated acute respiratory distress syndrome patients. Design: Prospective observational study. Setting: General ICU of a university hospital. Patients: Twenty-five consecutive sedated and paralyzed patients with acute respiratory distress syndrome (age 64 ± 15 yr, body mass index 26 ± 6 kg/m2, Pao2/Fio2147 ± 42, and positive end-expiratory pressure 9.3 ± 1.4 cm H2O) were enrolled. Interventions: A low-flow inflation and deflation pressure-volume curve (5-45 cm H2O) and a sustained inflation recruitment maneuver (45 cm H2O for 30 s) were performed. A lung CT scan was performed during breath-holding pressure at 5 cm H2O and during the recruitment maneuver at 45 cm H2O. Measurements and Main Results: Lung recruitment was computed as the difference in noninflated tissue and in gas volume measured at 5 and at 45 cm H2O. Hysteresis was calculated as the ratio of the area enclosed by the pressure-volume curve and expressed as the hysteresis ratio. Hysteresis was correlated with respiratory system compliance computed at 5 cm H2O and the lung gas volume entering the lung during inflation of the pressure-volume curve (R2= 0.749, p < 0.001 and R2= 0.851, p < 0.001). The hysteresis ratio was related to both lung tissue and gas recruitment (R2= 0.266, p = 0.008, R2= 0.357, p = 0.002, respectively). Receiver operating characteristic analysis showed that the optimal cutoff value to predict lung tissue recruitment for the hysteresis ratio was 28% (area under the receiver operating characteristic curve, 0.80; 95% CI, 0.62-0.98), with sensitivity and specificity of 0.75 and 0.77, respectively. Conclusions: Hysteresis of the respiratory system computed by low-flow pressure-volume curve is related to the anatomical lung characteristics and has an acceptable accuracy to predict lung recruitment.

Hysteresis and lung recruitment in acute respiratory distress syndrome patients : A CT scan study / D. Chiumello, J.-. Arnal, M. Umbrello, A. Cammaroto, P. Formenti, G. Mistraletti, L. Bolgiaghi, M. Gotti, D. Novotni, S. Reidt, S. Froio, S. Coppola. - In: CRITICAL CARE MEDICINE. - ISSN 0090-3493. - 48:10(2020 Oct), pp. 1494-1502. [10.1097/CCM.0000000000004518]

Hysteresis and lung recruitment in acute respiratory distress syndrome patients : A CT scan study

D. Chiumello
;
M. Umbrello;A. Cammaroto;P. Formenti;G. Mistraletti;L. Bolgiaghi;M. Gotti;S. Froio;S. Coppola
2020-10

Abstract

Objectives: Hysteresis of the respiratory system pressure-volume curve is related to alveolar surface forces, lung stress relaxation, and tidal reexpansion/collapse. Hysteresis has been suggested as a means of assessing lung recruitment. The objective of this study was to determine the relationship between hysteresis, mechanical characteristics of the respiratory system, and lung recruitment assessed by a CT scan in mechanically ventilated acute respiratory distress syndrome patients. Design: Prospective observational study. Setting: General ICU of a university hospital. Patients: Twenty-five consecutive sedated and paralyzed patients with acute respiratory distress syndrome (age 64 ± 15 yr, body mass index 26 ± 6 kg/m2, Pao2/Fio2147 ± 42, and positive end-expiratory pressure 9.3 ± 1.4 cm H2O) were enrolled. Interventions: A low-flow inflation and deflation pressure-volume curve (5-45 cm H2O) and a sustained inflation recruitment maneuver (45 cm H2O for 30 s) were performed. A lung CT scan was performed during breath-holding pressure at 5 cm H2O and during the recruitment maneuver at 45 cm H2O. Measurements and Main Results: Lung recruitment was computed as the difference in noninflated tissue and in gas volume measured at 5 and at 45 cm H2O. Hysteresis was calculated as the ratio of the area enclosed by the pressure-volume curve and expressed as the hysteresis ratio. Hysteresis was correlated with respiratory system compliance computed at 5 cm H2O and the lung gas volume entering the lung during inflation of the pressure-volume curve (R2= 0.749, p < 0.001 and R2= 0.851, p < 0.001). The hysteresis ratio was related to both lung tissue and gas recruitment (R2= 0.266, p = 0.008, R2= 0.357, p = 0.002, respectively). Receiver operating characteristic analysis showed that the optimal cutoff value to predict lung tissue recruitment for the hysteresis ratio was 28% (area under the receiver operating characteristic curve, 0.80; 95% CI, 0.62-0.98), with sensitivity and specificity of 0.75 and 0.77, respectively. Conclusions: Hysteresis of the respiratory system computed by low-flow pressure-volume curve is related to the anatomical lung characteristics and has an acceptable accuracy to predict lung recruitment.
acute respiratory distress syndrome; computed tomography scan; hysteresis; lung recruitment; pressure-volume curve
Settore MED/41 - Anestesiologia
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Utilizza questo identificativo per citare o creare un link a questo documento: http://hdl.handle.net/2434/829406
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