Introduction: Chronic spontaneous urticaria (CSU) is a frequent disorder in which activation of effector cells and histamine release can be induced via several distinct pathogenetic mechanisms. Much work has been carried out to identify biomarkers useful for classifying CSU patients, and to predict their response to currently available treatments. Areas covered: The recent literature dealing with CSU biomarkers was screened in PubMed and Google Scholar using ‘chronic spontaneous urticaria’, ‘biomarker’, ‘diagnosis’, ‘therapy’ and ‘treatment response’ as key words. The characteristics found in relevant papers were divided into clinical and serological biomarkers of (a) clinical severity/disease activity, and (b) response to treatments. Expert opinion: A diagnostic biomarker for CSU is still missing. Most biomarkers described so far do not seem to possess sufficient specificity for this disease. Basopenia and the activation of the coagulation cascade might be biomarkers of disease activity and severity, but information available so far is insufficient to consider their routine use. Markers suggesting IgG-mediated autoimmunity (autologous serum skin test, basophil activation/histamine release assays, low total IgE) seem to identify patients less prone to respond to omalizumab but responsive to cyclosporine. In contrast, ‘autoallergy’ (i.e. the presence of IgE to autoallergens), which is often associated with elevated IgE levels seems to identify patients who will respond to omalizumab.

Biomarkers of chronic spontaneous urticaria and their clinical implications / R. Asero, M. Cugno. - In: EXPERT REVIEW OF CLINICAL IMMUNOLOGY. - ISSN 1744-666X. - 17:3(2021 Mar), pp. 247-254. [10.1080/1744666X.2021.1882304]

Biomarkers of chronic spontaneous urticaria and their clinical implications

M. Cugno
Ultimo
2021

Abstract

Introduction: Chronic spontaneous urticaria (CSU) is a frequent disorder in which activation of effector cells and histamine release can be induced via several distinct pathogenetic mechanisms. Much work has been carried out to identify biomarkers useful for classifying CSU patients, and to predict their response to currently available treatments. Areas covered: The recent literature dealing with CSU biomarkers was screened in PubMed and Google Scholar using ‘chronic spontaneous urticaria’, ‘biomarker’, ‘diagnosis’, ‘therapy’ and ‘treatment response’ as key words. The characteristics found in relevant papers were divided into clinical and serological biomarkers of (a) clinical severity/disease activity, and (b) response to treatments. Expert opinion: A diagnostic biomarker for CSU is still missing. Most biomarkers described so far do not seem to possess sufficient specificity for this disease. Basopenia and the activation of the coagulation cascade might be biomarkers of disease activity and severity, but information available so far is insufficient to consider their routine use. Markers suggesting IgG-mediated autoimmunity (autologous serum skin test, basophil activation/histamine release assays, low total IgE) seem to identify patients less prone to respond to omalizumab but responsive to cyclosporine. In contrast, ‘autoallergy’ (i.e. the presence of IgE to autoallergens), which is often associated with elevated IgE levels seems to identify patients who will respond to omalizumab.
antihistamines; autoallergy; autoimmunity; biomarkers; Chronic urticaria; cyclosporine; omalizumab
Settore MED/09 - Medicina Interna
12-feb-2021
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/828632
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