Gemcitabine (2',2'-difluorodeoxy- cytidine, dFdC) is an analog of deoxycytidine. It is transformed to the active triphosphate (dFdCTP) after intracellular phosphorylation. Gemcitabine monophosphate is inserted into the DNA and inhibits DNA elongation as a false nucleotide. In contrast to other antimetabolites, an additional, altered nucleotide is inserted behind dFdC inhibiting repair mechanisms (masked chain termination).

Gemcitabine / M. Tani, L. Alinari, A. Broccoli, E. Derenzini, M. Fina, L. Gandolfi, E. Marchi, C. Pellegrini, V. Stefoni, F. Venturini, P.L. Zinzani. - In: HEMATOLOGY MEETING REPORTS. - ISSN 1970-7339. - 3:1(2009), pp. 90-93. ((Intervento presentato al convegno Now we know T-cell lymphomas better tenutosi a Bologna nel 2009 [10.4081/hmr.v3i1.542].

Gemcitabine

E. Derenzini;
2009

Abstract

Gemcitabine (2',2'-difluorodeoxy- cytidine, dFdC) is an analog of deoxycytidine. It is transformed to the active triphosphate (dFdCTP) after intracellular phosphorylation. Gemcitabine monophosphate is inserted into the DNA and inhibits DNA elongation as a false nucleotide. In contrast to other antimetabolites, an additional, altered nucleotide is inserted behind dFdC inhibiting repair mechanisms (masked chain termination).
Settore MED/15 - Malattie del Sangue
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/827376
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