BACKGROUND: A right hemicolectomy is among the most commonly performed operations for colon cancer, but modern high-quality, multination data addressing the morbidity and mortality rates are lacking.OBJECTIVE: This study reports the morbidity and mortality rates for right-sided colon cancer and identifies predictors for unfavorable short-term outcome after right hemicolectomy.DESIGN: This was a snapshot observational prospective study.SETTING: The study was conducted as a multicenter international study.PATIENTS: The 2015 European Society of Coloproctology snapshot study was a prospective multicenter international series that included all patients undergoing elective or emergency right hemicolectomy or ileocecal resection over a 2-month period in early 2015. This is a subanalysis of the colon cancer cohort of patients.MAIN OUTCOME MEASURES: Predictors for anastomotic leak and 30-day postoperative morbidity and mortality were assessed using multivariable mixed-effect logistic regression models after variables selection with the Lasso method.RESULTS: Of the 2515 included patients, an anastomosis was performed in 97.2% (n = 2444), handsewn in 38.5% (n = 940) and stapled in 61.5% (n = 1504) cases. The overall anastomotic leak rate was 7.4% (180/2444), 30-day morbidity was 38.0% (n = 956), and mortality was 2.6% (n = 66). Patients with anastomotic leak had a significantly increased mortality rate (10.6% vs 1.6% no-leak patients; p > 0.001). At multivariable analysis the following variables were associated with anastomotic leak: longer duration of surgery (OR = 1.007 per min; p = 0.0037), open approach (OR = 1.9; p = 0.0037), and stapled anastomosis (OR = 1.5; p = 0.041).LIMITATIONS: This is an observational study, and therefore selection bias could be present. For this reason, a multivariable logistic regression model was performed, trying to correct possible confounding factors.CONCLUSIONS: Anastomotic leak after oncologic right hemicolectomy is a frequent complication, and it is associated with increased mortality. The key contributing surgical factors for anastomotic leak were anastomotic technique, surgical approach, and duration of surgery. See Video Abstract at http://links.lww.com/DCR/B165.

Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: Results from an international snapshot audit / M. Frasson, N. Battersby, A. Bhangu, D. Hervas, A. El-Hussuna, G. Gallo, F. Pata, T. Pinkney, T. Poskus, B. Singh, S. Chaudhri, D. Nepogodiev, S. Vennix, O. Zmora, W. Bemelman, P. Christensen, A. D’Hoore, S. Laurberg, D. Morton, M. Rubbini, C. Vaizey, L. Magill, R. Perry, N. Sheward, M. Cillo, D. Estefania, J. Patron Uriburu, H. Ruiz, M. Solomon, A. Makhmudov, L. Selnyahina, A. Varabei, Y. Vizhynis, D. Claeys, B. Defoort, F. Muysoms, P. Pletinckx, V. Vergucht, I. Debergh, T. Feryn, H. Reusens, M. Nachtergaele, D. Francart, C. Jehaes, S. Markiewicz, B. Monami, J. Weerts, B. Houben, L. Haeck, C. Lange, C. Sommeling, K. Vindevoghel, S. Castro, H. De Bruyn, M. Huyghe, E. De Wolf, D. Reynders, A. de Buck van Overstraete, A. Wolthuis, S. Delibegovic, A. Christiani, M.M. Jr., C. Rocha de Moraes, V.T. Jr., E. Arabadjieva, D. Bulanov, D. Dardanov, V. Stoyanov, A. Yonkov, K. Angelov, S. Maslyankov, M. Sokolov, G. Todorov, S. Toshev, Y. Georgiev, A. Karashmalakov, G. Zafirov, X. Wang, V. Bencurik, E. Holášková, M. Skrovina, M. Farkašová, T. Grolich, Z. Kala, F. Antos, V. Pruchova, O. Sotona, M. Chobola, T. Dusek, A. Ferko, J. Örhalmi, J. Hoch, P. Kocian, L. Martinek, I. Bernstein, K. Gotschalck Sunesen, J. Leunbach, O. Thorlacius-Ussing, A. Uth Oveson, S. Dahl Chirstensen, V. Gamez, M. Oeting, U. Schou Loeve, A. Ugianskis, M. Jessen, P. Krarup, K. Linde, Q. Mirza, J. Overgaard Stovring, L. Erritzøe, H. Loft Jakobsen, J. Lykke, E. Palmgren Colov, A. Palmgren Colov, T. Linde Friis, J. Amstrup Funder, R. Dich, S. Kjær, S. Rasmussen, N. Schlesinger, M. Dilling Kjae, N. Qvist, A. Khalid, G. Ali, S. Hadi, L. Rosell Walker, A. Kivelä, T. Lehtonen, A. Lepistö, T. Scheinin, P. Siironen, J. Kössi, P. Kuusanmäki, T. Tomminen, A. Turunen, T. Rautio, M. Vierimaa, H. Huhtinen, J. Karvonen, M. Lavonius, A. Rantala, P. Varpe, E. 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Predictors for anastomotic leak, postoperative complications, and mortality after right colectomy for cancer: Results from an international snapshot audit

N. Mariani
Membro del Collaboration Group
;
2020

Abstract

BACKGROUND: A right hemicolectomy is among the most commonly performed operations for colon cancer, but modern high-quality, multination data addressing the morbidity and mortality rates are lacking.OBJECTIVE: This study reports the morbidity and mortality rates for right-sided colon cancer and identifies predictors for unfavorable short-term outcome after right hemicolectomy.DESIGN: This was a snapshot observational prospective study.SETTING: The study was conducted as a multicenter international study.PATIENTS: The 2015 European Society of Coloproctology snapshot study was a prospective multicenter international series that included all patients undergoing elective or emergency right hemicolectomy or ileocecal resection over a 2-month period in early 2015. This is a subanalysis of the colon cancer cohort of patients.MAIN OUTCOME MEASURES: Predictors for anastomotic leak and 30-day postoperative morbidity and mortality were assessed using multivariable mixed-effect logistic regression models after variables selection with the Lasso method.RESULTS: Of the 2515 included patients, an anastomosis was performed in 97.2% (n = 2444), handsewn in 38.5% (n = 940) and stapled in 61.5% (n = 1504) cases. The overall anastomotic leak rate was 7.4% (180/2444), 30-day morbidity was 38.0% (n = 956), and mortality was 2.6% (n = 66). Patients with anastomotic leak had a significantly increased mortality rate (10.6% vs 1.6% no-leak patients; p > 0.001). At multivariable analysis the following variables were associated with anastomotic leak: longer duration of surgery (OR = 1.007 per min; p = 0.0037), open approach (OR = 1.9; p = 0.0037), and stapled anastomosis (OR = 1.5; p = 0.041).LIMITATIONS: This is an observational study, and therefore selection bias could be present. For this reason, a multivariable logistic regression model was performed, trying to correct possible confounding factors.CONCLUSIONS: Anastomotic leak after oncologic right hemicolectomy is a frequent complication, and it is associated with increased mortality. The key contributing surgical factors for anastomotic leak were anastomotic technique, surgical approach, and duration of surgery. See Video Abstract at http://links.lww.com/DCR/B165.
Anastomotic leak; Colon cancer; Postoperative outcome; Right colectomy; Aged; Aged, 80 and over; Anastomotic Leak; Cohort Studies; Colectomy; Colonic Neoplasms; Female; Humans; Male; Medical Audit; Middle Aged; Risk Factors; Survival Rate
Settore MED/18 - Chirurgia Generale
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/827267
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