The TANGO trial demonstrated the efficacy of lamivudine plus dolutegravir in virologically suppressed patients without previous virological failures (VF). In this dataset from clinical practice investigating the impact of past NRTI resistance on this strategy, the combination of M184V/I plus at least one TAM significantly increased the risk of VF.

NRTI resistance mutations predict virological failure in HIV-positive patients during lamivudine plus dolutegravir maintenance therapy in clinical practice / A. Borghetti, A. Giacomelli, V. Borghi, A. Ciccullo, A. Dusina, M. Fabbiani, S. Rusconi, M. Zazzi, C. Mussini, S. Di Giambenedetto. - In: OPEN FORUM INFECTIOUS DISEASES. - ISSN 2328-8957. - (2021). [Epub ahead of print] [10.1093/ofid/ofab103]

NRTI resistance mutations predict virological failure in HIV-positive patients during lamivudine plus dolutegravir maintenance therapy in clinical practice

A. Giacomelli
Secondo
;
S. Rusconi;
2021

Abstract

The TANGO trial demonstrated the efficacy of lamivudine plus dolutegravir in virologically suppressed patients without previous virological failures (VF). In this dataset from clinical practice investigating the impact of past NRTI resistance on this strategy, the combination of M184V/I plus at least one TAM significantly increased the risk of VF.
HIV; lamivudine; dolutegravir; maintenance therapy; resistance-associated mutations;
Settore MED/17 - Malattie Infettive
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/826264
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