In this chapter we report about recent advances on the development and application of 2D and 3D plasmonic nanostructures used for sensing of biological samples by Raman spectroscopy at unprecedented resolution of analysis. Besides, we explain how the integration of these nanodevices in a microfluidic apparatus can simplify the analysis of biological samples. In the first part we introduce and motivate the convenience of using nanoplasmonic enhancers and Raman spectroscopy for biological sensing, describing the phenomena and the current approaches to fabricate nanoplasmonic structures. In the second part, we explain how specific multi-element devices produce the optimal enhancement of the Raman scattering. We report cases where biological sensing of DNA was performed at few molecules level with nanometer spatial resolutions. Finally, we show an example of microfluidic device integrating plasmonic nanodevices to sort and drive biological samples, like living cells, towards the optical probe in order to obtain optimal conditions of analysis.

Nanoplasmonic and microfluidic devices for biological sensing / G. Perozziello, A. Giugni, M. Allione, B. Torre, G. Das, M.L. Coluccio, M. Marini, L. Tirinato, M. Moretti, T. Limongi, P. Candeloro, E. Di Fabrizio (NATO SCIENCE FOR PEACE AND SECURITY SERIES. B, PHYSICS AND BIOPHYSICS). - In: Nano-Optics : Principles Enabling Basic Research and Applications / [a cura di] B. Di Bartolo, J. Collins, L. Silvestri. - Prima edizione. - Berlin : Springer, 2017 Feb 17. - ISBN 978-94-024-0869-0. - pp. 247-274 [10.1007/978-94-024-0850-8_12]

Nanoplasmonic and microfluidic devices for biological sensing

A. Giugni;
2017

Abstract

In this chapter we report about recent advances on the development and application of 2D and 3D plasmonic nanostructures used for sensing of biological samples by Raman spectroscopy at unprecedented resolution of analysis. Besides, we explain how the integration of these nanodevices in a microfluidic apparatus can simplify the analysis of biological samples. In the first part we introduce and motivate the convenience of using nanoplasmonic enhancers and Raman spectroscopy for biological sensing, describing the phenomena and the current approaches to fabricate nanoplasmonic structures. In the second part, we explain how specific multi-element devices produce the optimal enhancement of the Raman scattering. We report cases where biological sensing of DNA was performed at few molecules level with nanometer spatial resolutions. Finally, we show an example of microfluidic device integrating plasmonic nanodevices to sort and drive biological samples, like living cells, towards the optical probe in order to obtain optimal conditions of analysis.
Surface Enhance Raman Scattering; Microfluidic Device; Localize Surface Plasmon Resonance; Raman Signal; Field Enhancement
Settore FIS/03 - Fisica della Materia
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/826100
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