Generation of artificial vascular grafts as blood vessel substitutes is a primary challenge in biomaterial and tissue-engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behavior to withstand the pressure exerted by blood flow.

Three-dimensionally two-photon lithography realized vascular grafts / T. Limongi, L. Brigo, L. Tirinato, F. Pagliari, A. Gandin, P. Contessotto, A. Giugni, G. Brusatin. - In: BIOMEDICAL MATERIALS. - ISSN 1748-6041. - 16:3(2021). [10.1088/1748-605X/abca4b]

Three-dimensionally two-photon lithography realized vascular grafts

A. Giugni
Penultimo
;
2021

Abstract

Generation of artificial vascular grafts as blood vessel substitutes is a primary challenge in biomaterial and tissue-engineering research. Ideally, these grafts should be able to recapitulate physiological and mechanical properties of natural vessels and guide the assembly of an endothelial cell lining to ensure hemo-compatibility. In this paper, we advance on this challenging task by designing and fabricating 3D vessel analogues by two-photon laser lithography using a synthetic photoresist. These scaffolds guarantee human endothelial cell adhesion and proliferation, and proper elastic behavior to withstand the pressure exerted by blood flow.
microstructured scaffolds; 3D fabrication; two-photon laser lithography; endothelial cells; vascular tissue engineering
Settore FIS/07 - Fisica Applicata(Beni Culturali, Ambientali, Biol.e Medicin)
Settore BIO/13 - Biologia Applicata
Settore ING-IND/34 - Bioingegneria Industriale
1-mar-2021
Article (author)
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/825454
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