Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19.

Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy / K.S. Saini, C. Lanza, M. Romano, E. de Azambuja, J. Cortes, B. de las Heras, J. de Castro, M. Lamba Saini, S. Loibl, G. Curigliano, C. Twelves, M. Leone, M.M. Patnaik. - In: BRITISH JOURNAL OF CANCER. - ISSN 0007-0920. - 123:5(2020), pp. 694-697. [10.1038/s41416-020-0948-x]

Repurposing anticancer drugs for COVID-19-induced inflammation, immune dysfunction, and coagulopathy

G. Curigliano
Conceptualization
;
2020

Abstract

Three cardinal manifestations of neoplasia, namely inflammation, immune dysfunction, and coagulopathy are also seen in patients with severe SARS-CoV-2 infection, providing a biological rationale for testing selected anticancer drugs for their ability to control the symptoms and/or modify the course of COVID-19.
Adrenal Cortex Hormones; Anticoagulants; Antineoplastic Agents; COVID-19; Coronavirus Infections; Drug Repositioning; Humans; Immunologic Factors; Inflammation; Interleukin-6; Pandemics; Pneumonia, Viral; Programmed Cell Death 1 Receptor; Protein Kinase Inhibitors; SARS-CoV-2; Treatment Outcome; Vascular Endothelial Growth Factor A; Betacoronavirus
Settore MED/06 - Oncologia Medica
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/824761
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