Tris(1-chloro-2-propyl)phosphate (TCPP) is the most common chlorinated organophosphorus flame retardant in seawater. Due to its chemical features and abundance, TCPP has been classified as a high hazard, and restrictions of use have been set in multiple countries. Despite TCPP being highly present in the marine environment, only a few studies have explored the TCPP impact on the development of marine invertebrates. Ascidians are important invertebrate members of benthic marine communities and reliable model systems for ecotoxicological research. The aim of this study was to assess the adverse effects of TCPP exposure on the embryogenesis of the ascidian Ciona intestinalis. Our results showed that this pollutant affected both muscles and nervous system development. Malformations appeared similar to those reported in other animal models for other flame retardants, suggesting that these molecules could share a common mechanism of action and induce a mixture effect when simultaneously present in the aquatic environment even at sub-teratogenic concentrations.
Embryotoxicity characterization of the flame retardant tris(1-chloro-2-propyl)phosphate (TCPP) in the invertebrate chordate Ciona intestinalis / S. Mercurio, S. Messinetti, R. Manenti, G.F. Ficetola, R. Pennati. - In: JOURNAL OF EXPERIMENTAL ZOOLOGY. PART A, ECOLOGICAL AND INTEGRATIVE PHYSIOLOGY. - ISSN 2471-5646. - 335:3(2021 Mar), pp. 339-347.
|Titolo:||Embryotoxicity characterization of the flame retardant tris(1-chloro-2-propyl)phosphate (TCPP) in the invertebrate chordate Ciona intestinalis|
MERCURIO, SILVIA (Primo) [Membro del Collaboration Group] (Corresponding)
MESSINETTI, SILVIA (Secondo) [Membro del Collaboration Group]
MANENTI, RAOUL [Membro del Collaboration Group]
FICETOLA, GENTILE FRANCESCO (Penultimo) [Formal Analysis]
PENNATI, ROBERTA (Ultimo) [Supervision]
|Parole Chiave:||chlorinated organophosphorus flame retardant; marine invertebrate; muscle; myogenesis; nervous system; neural development|
|Settore Scientifico Disciplinare:||Settore BIO/05 - Zoologia|
|Data di pubblicazione:||mar-2021|
|Data ahead of print / Data di stampa:||gen-2021|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1002/jez.2446|
|Appare nelle tipologie:||01 - Articolo su periodico|