Objective: To assess the distribution of nine hole peg test (9-HPT) and its clinical correlates in a large sample of patients with multiple sclerosis (MS). Methods: Data was collected in a multi-centre, cross-sectional study involving 4 Italians MS centres. We collected demographic and clinical data of 363 patients (244 women, 199 men), including year of symptom onset, disease course, Expanded Disability Status Scale (EDSS). Results: A total of 206 (61.3%) patients scored >= 2 standard deviations (SDs) of normative values in both hands, while only 38 (11.3%) scored <1 SD from normative values at 9-HPT. We found ceiling and floor effects in mildly (EDSS < 3.0) and severely (EDSS > 6.0) impaired patients. Patients with a primary progressive disease course and those with a more severe disability level showed the large between-hand asymmetry. In multivariate models, predictors of unimanual and bimanual impairments were primary progressive course (odds ratio [OR] = 7.27, p = 0.001) and higher EDSS score (OR = 2.13 for each step, p < 0.001), respectively. Conclusion: We suggest that 9-HPT should be used with caution in patients with low or high disability levels. Between-hand asymmetry and stratification for age, disease course, and presence/absence of bilateral involvement should be taken into account for future study design.

Clinical correlates of 9-hole peg test in a large population of people with multiple sclerosis / C. Solaro, D. Cattaneo, G. Brichetto, L. Castelli, A. Tacchino, E. Gervasoni, L. Prosperini. - In: MULTIPLE SCLEROSIS AND RELATED DISORDERS. - ISSN 2211-0348. - 30(2019 May), pp. 1-8. [10.1016/j.msard.2019.01.043]

Clinical correlates of 9-hole peg test in a large population of people with multiple sclerosis

D. Cattaneo
Secondo
;
2019

Abstract

Objective: To assess the distribution of nine hole peg test (9-HPT) and its clinical correlates in a large sample of patients with multiple sclerosis (MS). Methods: Data was collected in a multi-centre, cross-sectional study involving 4 Italians MS centres. We collected demographic and clinical data of 363 patients (244 women, 199 men), including year of symptom onset, disease course, Expanded Disability Status Scale (EDSS). Results: A total of 206 (61.3%) patients scored >= 2 standard deviations (SDs) of normative values in both hands, while only 38 (11.3%) scored <1 SD from normative values at 9-HPT. We found ceiling and floor effects in mildly (EDSS < 3.0) and severely (EDSS > 6.0) impaired patients. Patients with a primary progressive disease course and those with a more severe disability level showed the large between-hand asymmetry. In multivariate models, predictors of unimanual and bimanual impairments were primary progressive course (odds ratio [OR] = 7.27, p = 0.001) and higher EDSS score (OR = 2.13 for each step, p < 0.001), respectively. Conclusion: We suggest that 9-HPT should be used with caution in patients with low or high disability levels. Between-hand asymmetry and stratification for age, disease course, and presence/absence of bilateral involvement should be taken into account for future study design.
9-hole peg test; Manual dexterity; Multiple sclerosis;
Settore MED/48 -Scienze Infermie.e Tecniche Neuro-Psichiatriche e Riabilitattive
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Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/823820
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