Rheumatoid arthritis (RA) is a chronic inflammatory disease that carries high social and economic costs and can lead to permanent disability. RA pathogenesis has not been completely elucidated yet. Extracellular vesicles (EVs) are membrane-contained vesicles released by cells playing a role in cell-to-cell communication and they could be involved in different diseases. Evidence on the involvement of EVs in RA is currently inconclusive. Therefore, a systematic review on the role of EVs in RA was performed in order to explore this relationship. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The research was conducted on PubMed, Scopus, and Embase up to March 5, 2020: 41 studies were analyzed out of 674 screened. The total plasmatic and synovial fluid (SF) EV number seems increased in RA as compared with healthy controls. Both RA plasma and SF contained EVs subpopulations of heterogenous origin, especially derived from platelets and immune system cells. No univocal evidence emerged on miRNA expression and EV content profile within RA patients. EVs showed to enhance pro-inflammatory pathways, such as cytokines and chemokine release and TNF blockade seemed to revert this effect. Our work highlights the requirement to standardize study methodologies in order to make results comparable and draw conclusions that remain, at present, unclear.

The role of extracellular vesicles in rheumatoid arthritis: a systematic review / T. Schioppo, T. Ubiali, F. Ingegnoli, V. Bollati, R. Caporali. - In: CLINICAL RHEUMATOLOGY. - ISSN 0770-3198. - 40:9(2021 Sep), pp. 3481-3497. [10.1007/s10067-021-05614-w]

The role of extracellular vesicles in rheumatoid arthritis: a systematic review

T. Schioppo
Primo
;
T. Ubiali
Secondo
;
F. Ingegnoli;V. Bollati
Penultimo
;
R. Caporali
Ultimo
2021

Abstract

Rheumatoid arthritis (RA) is a chronic inflammatory disease that carries high social and economic costs and can lead to permanent disability. RA pathogenesis has not been completely elucidated yet. Extracellular vesicles (EVs) are membrane-contained vesicles released by cells playing a role in cell-to-cell communication and they could be involved in different diseases. Evidence on the involvement of EVs in RA is currently inconclusive. Therefore, a systematic review on the role of EVs in RA was performed in order to explore this relationship. This review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. The research was conducted on PubMed, Scopus, and Embase up to March 5, 2020: 41 studies were analyzed out of 674 screened. The total plasmatic and synovial fluid (SF) EV number seems increased in RA as compared with healthy controls. Both RA plasma and SF contained EVs subpopulations of heterogenous origin, especially derived from platelets and immune system cells. No univocal evidence emerged on miRNA expression and EV content profile within RA patients. EVs showed to enhance pro-inflammatory pathways, such as cytokines and chemokine release and TNF blockade seemed to revert this effect. Our work highlights the requirement to standardize study methodologies in order to make results comparable and draw conclusions that remain, at present, unclear.
Exosomes; Extracellular vesicles; Microvesicles; Rheumatoid arthritis;
Settore MED/16 - Reumatologia
Settore MED/44 - Medicina del Lavoro
5-feb-2021
Article (author)
File in questo prodotto:
File Dimensione Formato  
TheRoleOfExtracellularVesicles (3).pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 866.68 kB
Formato Adobe PDF
866.68 kB Adobe PDF Visualizza/Apri
Schioppo2021_Article_TheRoleOfExtracellularVesicles.pdf

accesso aperto

Tipologia: Publisher's version/PDF
Dimensione 878.9 kB
Formato Adobe PDF
878.9 kB Adobe PDF Visualizza/Apri
Pubblicazioni consigliate

Caricamento pubblicazioni consigliate

I documenti in IRIS sono protetti da copyright e tutti i diritti sono riservati, salvo diversa indicazione.

Utilizza questo identificativo per citare o creare un link a questo documento: https://hdl.handle.net/2434/823189
Citazioni
  • ???jsp.display-item.citation.pmc??? 4
  • Scopus 6
  • ???jsp.display-item.citation.isi??? 7
social impact