Purpose: To assess the impact of perioperative chemotherapy on survival in cN+ BCa patients and analyze it according to the pN status. Methods: A retrospective analysis was conducted on 639 BCa patients with cTanyN1-3M0 BCa treated with radical cystectomy (RC) and bilateral lymph node dissection (LND) with or without perioperative chemotherapy in ten tertiary referral centers from 1990 to 2017. Selected cN+ patients received induction chemotherapy (IC), whereas adjuvant chemotherapy (ACT) was delivered to selected pN+ patients. Univariable and multivariable Cox regression analyses were used to predict overall mortality (OM) after surgery, adjusting for clinicopathological confounders. Kaplan–Meier analyses assessed OM according to the treatment modality. Results: Overall, 356 (56%) patients were treated with surgery alone, 155 (24%) with IC followed by surgery, and 128 (20%) with ACT following surgery. Over a median follow-up of 25 months, 316 deaths were recorded. At univariable analysis, patients treated with IC and surgery had lower OM both considering cN+ [hazard ratio (HR) 0.65, 95% confidence interval (CI) 0.49–0.87, p = 0.004] and cN+pN− patients (HR 0.61, 95% CI 0.37–0.99, p = 0.05) compared to those treated with surgery alone. cN+pN+ patients treated with ACT experienced lower OM compared to those treated with IC or surgery alone at multivariable analysis (HR 0.40, 95% CI 0.22–0.74, p = 0.003). Conclusion: Patients with cTany cN+ cM0 BCa benefit more in terms of OS when treated with IC followed by RC + LND compared to RC + LND alone, regardless of LNMs at final histopathology examination. More data are needed to assess the role of ACT in the management of cN+ patients.
The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration / L. Afferi, S. Zamboni, R.J. Karnes, F. Roghmann, P. Sargos, F. Montorsi, A. Briganti, A. Gallina, A. Mattei, G.B. Schulz, K. Hendricksen, C.S. Voskuilen, M. Rink, C. Poyet, O. De Cobelli, E. di Trapani, C. Simeone, M. Soligo, G. Simone, G. Tuderti, M. Alvarez-Maestro, L. Martinez-Pineiro, A. Aziz, S.F. Shariat, M. Abufaraj, E. Xylinas, M. Moschini. - In: WORLD JOURNAL OF UROLOGY. - ISSN 0724-4983. - 39:2(2021 Feb), pp. 443-451.
|Titolo:||The impact of treatment modality on survival in patients with clinical node-positive bladder cancer: results from a multicenter collaboration|
|Parole Chiave:||Bladder cancer; Clinical metastases; Induction chemotherapy; Multimodal treatment; Radical cystectomy; Urothelial cancer|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
|Data di pubblicazione:||feb-2021|
|Data ahead of print / Data di stampa:||apr-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1007/s00345-020-03205-z|
|Appare nelle tipologie:||01 - Articolo su periodico|