Objective: To compare outcomes of minimally invasive radical nephrectomy (MIS-RN) and robot-assisted partial nephrectomy (RAPN) in clinical T2a renal mass (cT2aRM). Patients and Methods: Retrospective, multicentre, propensity score-matched (PSM) comparison of RAPN and MIS-RN for cT2aRM (T2aN0M0). Cohorts were PSM for age, sex, body mass index, American Society of Anesthesiologists (ASA) class, clinical tumour size, and R.E.N.A.L. score using a 2:1 ratio for RN:PN. The primary outcome was disease-free survival (DFS). Secondary outcomes included overall survival (OS), complication rates, and de novo estimated glomerular filtration rate (eGFR) <45 mL/min/1.73 m2. Multivariable (MVA) and Kaplan–Meier survival analyses (KMSA) were conducted. Results: In all, 648 patients (216 RAPN/432 MIS-RN) were matched. There were no significant differences in intraoperative complications (P = 0.478), Clavien–Dindo Grade ≥III complications (P = 0.063), and re-admissions (P = 0.238). The MVA revealed high ASA class (hazard ratio [HR] 2.7, P = 0.044) and sarcomatoid (HR 5.3, P = 0.001), but not surgery type (P = 0.601) to be associated with all-cause mortality. Increasing R.E.N.A.L. score (HR 1.31, P = 0.037), high tumour grade (HR 2.5, P = 0.043), and sarcomatoid (HR 2.8, P = 0.02) were associated with recurrence, but not surgery (P = 0.555). Increasing age (HR 1.1, P < 0.001) and RN (HR 3.9, P < 0.001) were predictors of de novo eGFR of <45 mL/min/1.73 m2. Comparing RAPN and MIS-RN, KMSA revealed no significant differences for 5-year OS (76.3% vs 88.0%, P = 0.221) and 5-year DFS (78.6% vs 85.3%, P = 0.630) for pT2 RCC, and no differences for 3-year OS (P = 0.351) and 3-year DFS (P = 0.117) for pT3a upstaged RCC. The 5-year freedom from de novo eGFR of <45 mL/min/1.73 m2 was 91.6% for RAPN vs 68.9% for MIS-RN (P < 0.001). Conclusions: RAPN had similar oncological outcomes and morbidity profile as MIS-RN, while conferring functional benefit. RAPN may be considered as a first-line option for cT2aRM.
Robotic partial nephrectomy vs minimally invasive radical nephrectomy for clinical T2a renal mass: a propensity score-matched comparison from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group / A.W. Bradshaw, R. Autorino, G. Simone, B. Yang, R.G. Uzzo, F. Porpiglia, U. Capitanio, J. Porter, R. Bertolo, A. Minervini, C. Lau, K. Jacobsohn, A. Ashrafi, D. Eun, A. Mottrie, W.M. White, L. Schips, B.J. Challacombe, O. De Cobelli, C.M. Mir, A. Veccia, A. Larcher, A. Kutikov, M. Aron, P. Dasgupta, F. Montorsi, I.S. Gill, C.P. Sundaram, J. Kaouk, I.H. Derweesh. - In: BJU INTERNATIONAL. - ISSN 1464-4096. - 126:1(2020 Jul 01), pp. 114-123.
|Titolo:||Robotic partial nephrectomy vs minimally invasive radical nephrectomy for clinical T2a renal mass: a propensity score-matched comparison from the ROSULA (Robotic Surgery for Large Renal Mass) Collaborative Group|
|Parole Chiave:||carcinoma, renal cell; chronic kidney disease; disease-free survival; nephrectomy; robot-assisted partial nephrectomy; Stage 2; Carcinoma, Renal Cell; Disease-Free Survival; Female; Humans; Kidney Neoplasms; Male; Middle Aged; Neoplasm Staging; Nephrectomy; Retrospective Studies; Robotic Surgical Procedures; Tomography, X-Ray Computed; Treatment Outcome; Propensity Score|
|Settore Scientifico Disciplinare:||Settore MED/24 - Urologia|
|Data di pubblicazione:||1-lug-2020|
|Data ahead of print / Data di stampa:||giu-2020|
|Digital Object Identifier (DOI):||http://dx.doi.org/10.1111/bju.15064|
|Appare nelle tipologie:||01 - Articolo su periodico|